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Siegelman and colleagues demonstrate unexpected synergism of CD44 and VLA-4 during lymphocyte extravasation. This is the first time that molecules mediating rolling and firm adhesion have been shown to associate biochemically leading to direct functional cooperation.

Original publication

DOI

10.1016/s1074-7613(04)00083-4

Type

Journal article

Journal

Immunity

Publication Date

04/2004

Volume

20

Pages

361 - 362

Addresses

New York University School of Medicine, Skirball Institute of Molecular Medicine, Department of Pathology, Program in Molecular Pathogenesis, 540 First Avenue, New York, NY 10016, USA.

Keywords

T-Lymphocytes, Animals, Humans, Inflammation, Antigens, CD44, Integrin alpha4beta1, Cell Adhesion, Leukocyte Rolling