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A framework for quantitative analysis of the mechanisms underlying immunological synapse assembly has been recently developed. This model uses partial differential equations to describe the binding interactions of receptors and ligands, with the constraint that they are embedded in apposed deformable membranes linked to a cytoskeletal complex.

Original publication

DOI

10.1016/s1471-4906(02)02325-6

Type

Journal article

Journal

Trends in immunology

Publication Date

10/2002

Volume

23

Pages

500 - 502

Addresses

Biophysics Graduate Group, Dept of Chemistry, University of California, Berkeley, CA, USA.

Keywords

Intercellular Junctions, Animals, Humans, Receptors, Immunologic, Ligands, Kinetics, Mathematics, Models, Immunological