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Although intercellular adhesion molecule-1 (ICAM-1) has been implicated as a ligand in some LFA-1-dependent adhesion, its importance to T cell function has not been established. The present studies investigate the importance of ICAM-1 for human cytotoxic T lymphocytes (CTL), both in their formation of antigen-independent conjugates (AIC) and in their lysis of targets. Analysis of monoclonal antibody (mAb) inhibition of AIC formation indicate that ICAM-1 mAb 1 blocks (a) AIC formation with some but not all targets; (b) the LFA-1 pathway but not the CD2/LFA-3 pathway of adhesion; (c) by binding to the target cell, not the T cell. In studies of cell-mediated lysis (CML) ICAM-1 mAb inhibited lysis of some targets, such as U-937, that use ICAM-1 predominantly in AIC formation; CML on some other targets is not inhibited by ICAM-1 mAb. These data indicate that ICAM-1 is a ligand for AIC formation, antigen-specific CTL recognition and cytolysis of particular target cells. The data also indicate that ICAM-1 is not used in LFA-1-dependent CTL interactions with all kinds of target cells, suggesting the existence of alternative ligands for LFA-1.

Original publication

DOI

10.1002/eji.1830180423

Type

Journal article

Journal

European journal of immunology

Publication Date

04/1988

Volume

18

Pages

637 - 640

Addresses

Immunology Branch, National Cancer Institute, Bethesda.

Keywords

T-Lymphocytes, Cytotoxic, Humans, Membrane Glycoproteins, Cell Adhesion Molecules, Lymphocyte Function-Associated Antigen-1, Antigens, CD18, Antibodies, Monoclonal, Antigens, Antigens, Surface, Ligands, Immunologic Techniques, Cell Adhesion, Cytotoxicity, Immunologic, Immunity, Cellular