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Autophagy is crucial during tissue development, as the developing cell has to constantly adapt to cell-intrinsic and environmental changes. For instance, protein aggregates need to be cleared, superfluous organelles removed and cell shape adapted to the new function of the cell. One typical example of such a developmental adaptation is that of the red blood cell (RBC). In order to reach the smallest capillaries, the RBC has to reduce its size considerably and the nucleus is expelled from the developing RBC. However, it is still unclear how unwanted proteins, RNA and organelles are cleared during erythroid development. Using an autophagy-deficient murine model we show that mitophagy plays a nonredundant role in the developmental clearance of mitochondria in the erythroid lineage.

Original publication

DOI

10.4161/auto.6.3.11528

Type

Journal article

Journal

Autophagy

Publication Date

15/04/2010

Volume

6

Pages

423 - 425

Addresses

University of Oxford, Nuffield Department of Medicine, Biomedical Research Center NIHR, Oxford, Oxfordshire, UK.

Keywords

Erythrocytes, Mitochondria, Animals, Mice, Knockout, Mice, Microtubule-Associated Proteins, Autophagy, Autophagy-Related Protein 7