Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies.

Silva M., Daheron L., Hurley H., Bure K., Barker R., Carr AJ., Williams D., Kim H-W., French A., Coffey PJ., Cooper-White JJ., Reeve B., Rao M., Snyder EY., Ng KS., Mead BE., Smith JA., Karp JM., Brindley DA., Wall I.

Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

DOI

10.1016/j.stem.2014.12.013

Type

Journal article

Journal

Cell stem cell

Publication Date

08/01/2015

Volume

16

Pages

13 - 17

Keywords

Animals, Cell Culture Techniques, Cellular Reprogramming, Humans, Induced Pluripotent Stem Cells, Reproducibility of Results, Stem Cell Transplantation

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