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This review considers adipokines as predictive biomarkers for early onset post-traumatic knee osteoarthritis (KOA). Serum concentrations of leptin and resistin can predict radiographic changes and are elevated in early KOA, with higher leptin concentrations independently associated with more severe knee changes. Plasma concentrations of resistin are chronically elevated after injury. Leptin, resistin, chemerin and vistfatin induce catabolic enzymes associated with cartilage degeneration. Available literature on adipokines in post-traumatic KOA pathogenesis suggests that they could contribute to risk prediction of early onset post-traumatic KOA. Further research is needed to further understand the association between adipokines, synovitis and long-term outcomes in this population.

Original publication




Journal article


Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Publication Date





519 - 525


a Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK .


Cartilage, Articular, Bone and Bones, Synovial Membrane, Knee Joint, Animals, Humans, Osteoarthritis, Knee, Knee Injuries, Acute Disease, Early Diagnosis, Prognosis, Predictive Value of Tests, Up-Regulation, Adipokines, Biomarkers