Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

BACKGROUND: The aim of this study was to review the evidence regarding the use of low intensity pulsed ultrasound (LIPUS) in the management of acute long bone fractures. METHODS: Systematic review of Medline, Embase, and CINAHL databases. Further published studies were retrieved by hand searching bibliographies of relevant articles. Retrieved studies were limited to English-language studies published since 1956. Retrieved studies were excluded from review using the following criteria: case reports, exclusively pathologic fractures, treatment of therapeutic osteotomies and arthrodesis, initiation of ultrasound therapy after the first month following injury, no reporting of assessment of time to fracture healing, cellular studies, and nonclinical articles. Studies were reviewed independently by two reviewers using the CONSORT score. No statistical analysis was performed as the data from the studies were not suitable for pooled analysis. RESULTS: Seven randomized controlled trials and two meta-analyses were retrieved using the search strategy. CONCLUSION: The literature supports the use of LIPUS in the treatment of acute fractures treated with plaster immobilization.

Original publication




Journal article


J trauma

Publication Date





1446 - 1452


Double-Blind Method, Evidence-Based Medicine, Fracture Healing, Fractures, Bone, Humans, Meta-Analysis as Topic, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Ultrasonic Therapy