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To quantify the magnitude and distribution of osteoporosis in rheumatoid arthritis (RA).Bone mineral density (BMD) was measured by dual x-ray absorptiometry, in a monozygotic co-twin control study.BMD was reduced at most skeletal sites in the twin with RA compared with the co-twin (lumbar spine 4.6%, femoral neck 9.7%, total body 5.7%). Differences in lean soft tissue (5.6% for total body) correlated with differences in BMD between twins at multiple sites.Osteoporosis in RA is generalized and may be related to loss of mobility or muscle mass associated with the disease.

Original publication

DOI

10.1002/art.1780380614

Type

Journal article

Journal

Arthritis and rheumatism

Publication Date

06/1995

Volume

38

Pages

806 - 809

Addresses

Garvan Institute of Medical Research, St. Vincent's Hospital, Sydney, Australia.

Keywords

Femur Neck, Lumbar Vertebrae, Humans, Osteoporosis, Arthritis, Rheumatoid, Diseases in Twins, Registries, Regression Analysis, Twins, Monozygotic, Bone Density, Female, Male, Surveys and Questionnaires, United Kingdom