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Recent epidemiologic research on scleroderma has been directed toward both genetic and environmental factors. The nature of any genetic contribution is unknown, although the major histocompatibility complex region is important in determining antibody response. Environmentally, an occupational basis in a small proportion of cases seems likely. There is no evidence to support the hypothesis that silicone gel breast implants are an important risk factor in the development of scleroderma.

Type

Journal article

Journal

Current opinion in rheumatology

Publication Date

11/1994

Volume

6

Pages

607 - 611

Addresses

ARC Epidemiology Research Unit, University of Manchester, UK.

Keywords

Humans, Scleroderma, Systemic, Prognosis, Risk Factors, Environmental Exposure, Occupational Exposure, Female, Male