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Phagocytosis is key for many organismal functions. In a recent issue of Cell, Freeman et al. (2016) demonstrate a feed-forward signaling mechanism wherein F-actin and integrin receptors drive contact formation between phagocytes and antibody-coated solid particles, signaling their engulfment. This mechanism translates nanoscale proximity effects into wider self-propagating signals.

Original publication

DOI

10.1016/j.devcel.2016.01.004

Type

Journal article

Journal

Developmental cell

Publication Date

01/2016

Volume

36

Pages

131 - 132

Addresses

The Kennedy Institute of Rheumatology, The University of Oxford, Oxford OX3 7FY, UK. Electronic address: michael.dustin@kennedy.ox.ac.uk.

Keywords

Phagocytes, Animals, Humans, Actins, Integrins, Signal Transduction, Phagocytosis, Actin Cytoskeleton