Role of PD-1/PD-L1 in acute and chronic graft versus host disease
Blazar BR., O'Connor RS., Milone MC., Dustin ML., Riley JL., Vincent BG., Serody JS., Flynn RP., Paz K., Du J., Panoskaltsis-Mortari A., Jeffrey M., Ahmed R., Turka LAA., Freeman GJ., Sharpe AH., Saha A.
Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important role in the maintenance of peripheral tolerance. PD-1 is an inhibitory receptor that attenuates TCR signaling. Its expression is inducible on T-cells, B-cells, NKT-cells, and activated monoytes. Interactions between PD-1 and its ligands deliver inhibitory signals that regulate T-cell activation, tolerance, and immune-mediated tissue damage.