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Cortical F-actin plays important roles during HIV-1 infection. A recent paper in Cell highlights the involvement of F-actin in enhancing dendritic cell (DC)-mediated HIV-1 infection of T cells. Such a critical mechanism of HIV-1 trans-enhancement between human DCs and T cells had not been analyzed in molecular detail before this work.

Original publication

DOI

10.1016/j.molmed.2016.03.007

Type

Journal article

Journal

Trends in molecular medicine

Publication Date

14/04/2016

Addresses

Division of Structural Biology, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK; Wellcome Trust Human Genetics, Cellular Imaging Core, University of Oxford, Oxford, UK. Electronic address: spadilla@well.ox.ac.uk.