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Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission.

Original publication

DOI

10.1038/ncb3381

Type

Journal article

Journal

Nat cell biol

Publication Date

28/06/2016

Volume

18

Pages

724 - 726

Keywords

Animals, Cytoplasm, Homeostasis, Humans, Proteasome Endopeptidase Complex, Protein Folding, Protein Transport, Ubiquitin-Protein Ligases