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Cytokines are soluble mediators of cell communication that are critical in immune regulation. They induce specific gene-expression programs in responsive cells. Recent findings, however, indicate that cytokine receptors can regulate immune cell functions by transcription-independent mechanisms. Here we review the current understanding of how cytokine signaling regulates the functions of other signaling pathways by first discussing the 'traditional' transcription-mediated consequences of cytokine signaling and then providing a detailed description of transcription-independent lateral communications between cytokine receptors and other cellular receptors.

Original publication

DOI

10.1038/ni.1713

Type

Journal article

Journal

Nature immunology

Publication Date

04/2009

Volume

10

Pages

333 - 339

Addresses

Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA. jelena.bezbradica@yale.edu

Keywords

Animals, Humans, Receptors, Cytokine, Cytokines, Cell Communication, Signal Transduction, Receptor Cross-Talk, Transcription, Genetic, Models, Biological, STAT Transcription Factors, Janus Kinases