The transcriptional effects of thermal injury and cooling on human skin and implications for wound healing
Wright H., Tyler M., Harris AL., Furniss D.
Cooling has a key role in burns first aid, but no clear mechanism. We have developed an ethically-approved, validated in vivo human model for cooling of partial-thickness burns utilising bilateral areas of abdominal skin discarded during DIEP surgery. Aims To create cooled and uncooled burns and controls in volunteers, and sequence their RNA for transcriptional changes caused by burning and cooling.