Oxidative stress in endometriosis induces IL-8 release directly via 4-HNE
Elger BJ., Mueller J., Morton KJ., Kessler B., Becker CM., Steers G., Thezenas M-LR., Zondervan KT., Zollner TM., Oppermann U.
Lipid peroxidation products, e.g. 4-hydroxynonenal (4-HNE), are generated by oxidative stress, and are suggested to cause endometriosis-associated pain following iron overload after retrograde menstrual bleeding. Our aim was to determine the role of oxidative stress including 4-HNE protein adduct formation in endometriotic lesions and in peritoneal fluid from endometriosis patients; and characterise the proinflammatory effects caused by 4-HNE in endometriosis.