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The best indirect evidence that increased bone turnover contributes to fracture risk is the fact that most of the proven therapies for osteoporosis are inhibitors of bone turnover. The evidence base that we can use biochemical markers of bone turnover in the assessment of fracture risk is somewhat less convincing. This relates to natural variability in the markers, problems with the assays, disparity in the statistical analyses of relevant studies and the independence of their contribution to fracture risk. More research is clearly required to address these deficiencies before biochemical markers might contribute a useful independent risk factor for inclusion in FRAX(®).

Original publication

DOI

10.1016/j.jocd.2011.05.008

Type

Journal article

Journal

J clin densitom

Publication Date

07/2011

Volume

14

Pages

220 - 222

Keywords

Absorptiometry, Photon, Biomarkers, Bone Density, Bone Remodeling, Diagnosis, Computer-Assisted, Femur Neck, Fractures, Bone, Humans, Osteoporosis, Osteoporotic Fractures, Risk Assessment, Risk Factors