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Optical tomography is being developed as a means of detecting and specifying disease in the adult female breast. We present a series of clinical three-dimensional optical images obtained with a 32-channel time-resolved system and a liquid-coupled interface. Patients place their breasts in a hemispherical cup to which sources and detectors are coupled, and the remaining space is filled with a highly scattering fluid. A cohort of 38 patients has been scanned, with a variety of benign and malignant lesions. Images show that hypervascularization associated with tumors provides very high contrast due to increased absorption by hemoglobin. Only half of the fibroadenomas scanned could be observed, but of those that could be detected, all but one revealed an apparent increase in blood volume and a decrease in scatter and oxygen saturation.

Original publication

DOI

10.1364/ao.46.003628

Type

Journal article

Journal

Appl opt

Publication Date

10/06/2007

Volume

46

Pages

3628 - 3638

Keywords

Adult, Aged, Aged, 80 and over, Breast, Breast Neoplasms, Cohort Studies, Female, Fibroadenoma, Hemoglobins, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Mammography, Middle Aged, Tomography, Optical