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Researchers in the Dustin Group reveal supramolecular attack particles are autonomous killing entities released from cytotoxic T lymphocytes

Close up of SMAP particles
Cryo-soft-x-ray tomography projection of a CD8+ T cell interacting with a carbon coated EM grid containing ICAM-1 and anti-CD3e (left). SMAPs (middle) can be observed within the multicore granules inside the cell. dSTORM images of an individual SMAP positive for perforin (green), WGA (orange) and granzyme B (magenta) released by CD8+ T cells (right)

Understanding the tissue biology of thyroid eye disease

Neutrophil subset behaviour in vascular and tissue microenvironment: organ-on-a-chip*

Cross-tissue and cross-disease immunometabolic landscape characterisation at single-cell resolution*

A spatial-transcriptomics based investigation of a gut origin for Ankylosing Spondylitis

A spatial-transcriptomics based investigation of a gut origin for Ankylosing Spondylitis

Investigating the Microbiome as a Driver of Inflammation and Growth Following Acute Illness

Host microbe cross talk in the intestine in health and disease

Granulopoiesis: chromatin topology and associated functions

Genomic landscape of neutrophil states in inflammation: morphology, behaviour, function, and interactions

The kynurenine pathway and chronic inflammatory disease

Regulation of Treg localisation during infection

Regulation of Treg localisation during infection

Identifying drivers of immune-mediated disease risk and therapeutic targets via multi-omics integration

Unravelling functional cartilage repair in osteoarthritis: a multidisciplinary approach

Quantifying the mechanosensation of T-cell activation exploiting advanced force probing technologies

Roles and mechanism of cytoskeletal filaments coordination in immunity and cell migration

Roles and mechanism of cytoskeletal filaments coordination in immunity and cell migration

Targeting cytokine variants for improved control of inflammatory disease

The role of immunity in cardiovascular disease

The role of vascular macrophages in cardiovascular health and disease

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Supramolecular attack particles are autonomous killing entities released from cytotoxic T cells

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