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CHARIOT
This is a multi-centre, open label, 2 stage trial in patients with oesophageal cancer
TWO
This is a study to assess cell therapy as a treatment to prevent kidney transplant rejection. Patients will be randomly assigned to either receive standard medication after transplant or a modified regimen including the cell product.
CEDAR
CEDAR: Chemoradiation with Enadenotucirev as a radiosensitiser in locally advanced colorectal cancer
DOC-MEK
This is a multi-centre randomised trial of docetaxel with or without AZD6244 in advanced melanoma
PART
The PART study is a feasibility study comparing partial ablation (PA) and radical prostatectomy (RP) in men with intermediate risk unilateral prostate cancer. The aim of the feasibility is to determine whether or not it is possible to recruit and randomise men to a trial of this nature.
POISE
Clinical effectiveness of symptomatic therapy compared to standard step up care for the treatment of low impact psoriatic oligoarthritis: a 2 arm parallel group feasibility study
STARR2
Delivering personalised care in the management of exacerbations of chronic obstructive pulmonary disease: A multi-centre randomised clinical trial.
REGENERATE
This is a multi-centre, non-randomised trial of gene therapy in those with the condition choroideremia.
HOME
How can we best address prolonged hospital stays in older inpatients with medical-psychiatric multimorbidity?
OTTER-2
A randomised controlled trial into the effectiveness and efficacy of splints in thumb based osteoarthritis.
PReSuTINeB
A randomized placebo-controlled study in patients with neurogenic bladder dysfunction and recurrent urinary tract infections (UTIs)
ATOM
This pre-operative window of opportunity study will use functional imaging and serological investigations to assess whether atovaquone significantly reduces tumour hypoxia in patients with non-small cell lung cancer.
IMAGO
A single arm exploratory study examining the feasibility of imaging glioblastoma pH using CEST MRI
STIFF
Our aim is to conduct a randomised trial in order to determine the clinical and cost effectiveness of intra-medullary nails versus external fixation for segmental tibial fractures.
TROMBONE
Testing Radical prostatectomy in men with prostate cancer and oligoMetastases to the bone: a randomised controlled feasibility trial
WHISH
What is the rate of deep infection after hip fracture surgery in patients with negative pressure wound therapy compared to standard care wound management?
SPARC
This is a multi-centre Phase I trial of pre-operative, margin intensive, stereotactic body radiation therapy (SBRT) for previously untreated borderline resectable pancreatic cancer.
LINES
This is a multi-centre international Phase 2 trial of Linsitinib in advanced Ewing Sarcoma