Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences

SCIENCE

Surgery or Cast for Injuries of the EpicoNdyle in Children’s Elbows: A multi-centre prospective randomised superiority trial of operative fixation versus non-operative treatment for medial epicondyle fractures of the humerus.

6MP

This is a multi-centre randomised phase 2 trials in patients with known BRCA Defective Tumours

BKM120

This is a single centre Phase 1 trial of the PI3K inhibitor BKM120, given concomitantly with palliative radiotherapy for the treatment of Non-Small Cell Lung Cancer (NSCLC).

FOXFIRE

This is a multi-centre randomised trial of chemotherapy with chemotherapy plus radioembolisation for colorectal cancer that has spread to the liver

LASER

This is a multi-centre randomised, double blind, placebo-controlled, parallel group trial of the effectiveness of the nocturnal use of a Temperature Controlled Laminar Airflow (TLA) Device (Airsonett®) in adults with poorly-controlled, severe allergic asthma

OXO-PCR-01

This is a single-centre prospective phase 0 tranlational study for predicting response of high grade serious ovarian cancers to paclitaxel chemotherapy

PD-SAFE

This is a multi-centre randomised controlled trial of a treatment patient aimed to reduce the frequency of falls in those with Parkinson's disease.

SPRAINED

This is a validation study on a prognostic tool for ankle sprains

TARDOX

This is a phase 1 non-randomised trial to investigate the feasibility of targeted release of Doxorubicin from Lyso-thermosensitive Liposomal (LTSL) Doxorubicin (ThermoDox (R) using focused ultrasound in patients with liver metastases from lung, breast or colorectal primary tumours.

MErCuRIC-1

This is a multi-centre European Phase 1 study of MEK1/2 inhibitor PD-0325901 with c-MET inhibitor PF-02341066 in KRASMT and KRASWT (with aberrant c-MET) Colorectal Cancer Patients.

UK-TAVI

The UK TAVI trial is a multi-centre randomised controlled trial to assess the clinical effectiveness and cost-utility of TAVI, compared with conventional surgical aortic valve replacement, in patients with severe symptomatic aortic stenosis, who are at intermediate or high operative risk.

RAMPP

This is a multi-centre randomised study investigating ambulatory chest catheter drainage devices in the treament of primary pneumothorax.

POISE

Clinical effectiveness of symptomatic therapy compared to standard step up care for the treatment of low impact psoriatic oligoarthritis: a 2 arm parallel group feasibility study

BIOYARN

A feasibility and efficacy trial evaluating a suturing augmentation device for rotator cuff repairs

HAND OA

More information coming soon

MACRO

This NIHR Programme aims to provide high quality evidence to establish best practice for the management of this common sinus disease. The large multi-disciplinary MACRO research team have come together to tackle the disease from many different aspects – across primary and secondary care, and from a clinical, economic and patient perspective.

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