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CRAFFT
Children’s Radius Acute Fracture Fixation Trial. A multi-centre prospective randomized non- inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children.
Dakin Group | Soft Tissue Joint Disease
The Dakin Group undertakes translational research focusing on identifying the cellular and molecular basis of inflammatory fibrotic soft tissue joint diseases, with research programmes on tendinopathy, frozen shoulder and knee arthrofibrosis. Understanding the cellular and molecular basis of these diseases will inform new therapeutic approaches targeting tissue resident stromal cells of the joint, to promote resolution of inflammatory fibrotic disease.
STIFF-F
Segmental Tibial fractures, reamed Intramedullary nailing versus circular Frame external Fixation A feasibility study
WHITE-9
A multi centre randomised controlled trial comparing intra operative cell salvage with standard care in the treatment of hip fractures
FAME
The Fractured Ankle Management Evaluation
ART
ART (Arterial Revascularisation Trial) is led by Professor David Taggart, Professor of Cardiovascular Surgery, University of Oxford.
HOPE-e
Hand Osteoarthritis: investigating Pain Effects in a randomised placebo-controlled feasibility study of estrogen-containing therapy (HOPE-e)
UK TAVI
The UK TAVI Trial is a multi-centre randomised controlled trial to assess the clinical effectiveness and cost-utility of TAVI, compared with conventional surgical aortic valve replacement.
SCIENCE
Surgery or Cast for Injuries of the EpicoNdyle in Children’s Elbows: A multi-centre prospective randomised superiority trial of operative fixation versus non-operative treatment for medial epicondyle fractures of the humerus.
6MP
This is a multi-centre randomised phase 2 trials in patients with known BRCA Defective Tumours
BKM120
This is a single centre Phase 1 trial of the PI3K inhibitor BKM120, given concomitantly with palliative radiotherapy for the treatment of Non-Small Cell Lung Cancer (NSCLC).
FOXFIRE
This is a multi-centre randomised trial of chemotherapy with chemotherapy plus radioembolisation for colorectal cancer that has spread to the liver
LASER
This is a multi-centre randomised, double blind, placebo-controlled, parallel group trial of the effectiveness of the nocturnal use of a Temperature Controlled Laminar Airflow (TLA) Device (Airsonett®) in adults with poorly-controlled, severe allergic asthma
OXO-PCR-01
This is a single-centre prospective phase 0 tranlational study for predicting response of high grade serious ovarian cancers to paclitaxel chemotherapy
PD-SAFE
This is a multi-centre randomised controlled trial of a treatment patient aimed to reduce the frequency of falls in those with Parkinson's disease.
SPRAINED
This is a validation study on a prognostic tool for ankle sprains
TARDOX
This is a phase 1 non-randomised trial to investigate the feasibility of targeted release of Doxorubicin from Lyso-thermosensitive Liposomal (LTSL) Doxorubicin (ThermoDox (R) using focused ultrasound in patients with liver metastases from lung, breast or colorectal primary tumours.