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The Aspirin Esomeprazole Chemoprevention Trial (AspECT) is to our knowledge one of the largest cancer prevention trials using aspirin and acid suppression in the world. In total 2557 patients with a common precancerous change in their oesophagus, called Barrett’s oesophagus, were followed up for an average of 9 years resulting in over 20,000 life-years of follow up. After informed written consent, patients were randomly allocated to four different combinations; Low acid suppression alone, High acid suppression alone, low acid suppression with 300mg aspirin and high acid suppression with 300mg aspirin. We wanted to see if we could prevent progression to local cancer/cancer in-situ (high grade dysplasia), invasive cancer or prevent death by all causes both cancer and non-cancer.
Post-acute infection syndrome is not unique to COVID-19
Botnar Coronavirus COVID-19 Main Statistics and epidemiology
25 October 2024
Patients hospitalised with COVID-19 often report a wide range of symptoms months after their initial illness. But a new study from NDORMS shows that post-acute infection syndrome (PAIS) is not unique to COVID-19 and can also occur after other respiratory infections.
Cellular roadmap reveals new paths to treating inflammatory bowel disease
Inflammation biology Main Research
22 October 2024
In a world first, researchers at the Kennedy Institute, Oxford have mapped the cellular dynamics following treatment with the most commonly used advanced therapy in autoimmune diseases. They have discovered why some patients benefit from this therapy while others do not, potentially paving the way for new therapies.
New MSc course comes to NDORMS
Department Main
22 October 2024
The MSc in Experimental and Translational Therapeutics (ETT) is moving to NDORMS. Jointly run with the Department of Continuing Education, the move will expand the already broad range of disciplines covered in the course.
World Arthritis Day 2024 - Empowering patients in rheumatology
Arthritis Main
12 October 2024
To mark World Arthritis Day, the British Society for Rheumatology has announced the launch of a new toolkit that will help patients take more control of their arthritis treatment.
Translational funding enables preclinical trial of new treatment for torn ACL injuries
Funding Main
2 October 2024
NDORMS researchers have received funding from the Medical Research Council (MRC) to explore a new treatment for anterior cruciate ligament (ACL) injuries which could provide relief for thousands of young people suffering from knee pain.
Dr Kate Coldwell awarded Daphne Jackson Fellowship to study links between liver disease and gut bacteria
Kennedy Main
17 September 2024
Dr Kate Coldwell has joined the Oxford Centre for Microbiome Studies at the Kennedy Institute to study the links between liver disease and gut bacteria, having been awarded the Daphne Jackson Fellowship, co-funded by the Kennedy Trust for Rheumatology Research (KTRR) and the Medical Research Council.
Kennedy scientists honoured with Royal Society Medal
Awards Kennedy Main
16 September 2024
Professor Sir Ravinder Maini and Professor Sir Marc Feldmann have jointly received The Royal Society’s Royal Medal (Applied) for inventing anti-TNF therapy to treat rheumatoid arthritis (RA), bringing it from bench to bedside in one of the biggest success stories of modern medicine.
NDORMS researchers honoured in the Recognition of Distinction Scheme 2024
Awards Department Main
4 September 2024
Tal Arnon, Stephanie Dakin and Catherine Swales have each been awarded title of ‘Full Professor’ in the University of Oxford's 2024 Recognition of Distinction exercise.
CRUK funding will help develop new targets for ovarian cancer
Kennedy Main
21 August 2024
Irina Udalova has received funding from Cancer Research UK (CRUK) to study the diverse role of neutrophils in ovarian cancer.
NDORMS joins the Human Functional Genomics Initiative
Botnar Funding Main
19 August 2024
£28.5m in funding has been announced to support functional genomics research across the UK, including a research cluster at NDORMS that will deliver insights into musculoskeletal health and disease.
Healthy lifestyle lowers the risk of post-COVID complications
Botnar Coronavirus COVID-19 Main Statistics and epidemiology
13 August 2024
A new NDORMS study has found that a healthy lifestyle can significantly reduce the risk of post-COVID complications, hospitalisation, and death.
New donation secures future of Emergency Medicine research at Oxford
Main Orthopaedics and trauma Trauma
7 August 2024
A new research programme in emergency medicine begins today at the University of Oxford following a donation from the Kadoorie Foundation.
New prediction model could help inform patients of their risks of having shoulder replacement surgery
Botnar Main Orthopaedics and trauma Publication Shoulder
31 July 2024
A new model to predict the risk of serious complications after shoulder replacement surgery has been developed in a collaboration between researchers from the University of Oxford, University of Bristol, and University of Copenhagen. The model could be an important tool to help both patients and doctors make more informed decisions about this common procedure.
The evolving single-cell and spatial technology landscape
Main
17 July 2024
The scTrends consortium has published its first report that sheds light on the current state of the commercial single-cell and spatial genomics industry and its potential impact on drug discovery and patient care.
NDORMS tests AI algorithms for medical diagnoses
Botnar Main
3 July 2024
NDORMS has joined RAIQC as one of eight other NHS, industry and academic consortium partners in Trustworthy AI Evaluation.
New PI will study human iron metabolism, kinetics and physiology in health and inflammatory disease
Botnar Main
26 June 2024
We welcome Nicole Stoffel who has joined the Botnar Institute as a new Principal Investigator. Nicole will be establishing her group to better understand human iron metabolism, kinetics and physiology with a specific focus on the role iron plays in the immune response and the impact of iron deficiency on vaccine effectiveness.
Maryam Nina Hardy elected as President of the Oxford University Africa Society
Awards Main
24 June 2024
Kennedy DPhil student Maryam Nina Hardy has been elected as President of the Oxford University Africa Society.
Uncovering the cellular secrets of healthy tendons
Botnar Main Research
24 June 2024
Research has unveiled the intricate cellular landscape of healthy human hamstring tendons, shedding new light on this vital yet often overlooked component of our musculoskeletal system.