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The Aspirin Esomeprazole Chemoprevention Trial (AspECT) is to our knowledge one of the largest cancer prevention trials using aspirin and acid suppression in the world. In total 2557 patients with a common precancerous change in their oesophagus, called Barrett’s oesophagus, were followed up for an average of 9 years resulting in over 20,000 life-years of follow up. After informed written consent, patients were randomly allocated to four different combinations; Low acid suppression alone, High acid suppression alone, low acid suppression with 300mg aspirin and high acid suppression with 300mg aspirin. We wanted to see if we could prevent progression to local cancer/cancer in-situ (high grade dysplasia), invasive cancer or prevent death by all causes both cancer and non-cancer.
OCTRU Extended Training Bite: Introduction to the Trial Master File (TMF) *online*
Thursday, 03 December 2026, 10am to 12pm
OCTRU Workshop: EDI & Research Inclusion in Trials *in-person*
Monday, 20 April 2026, 1pm to 3.30pm
OCTRU Workshop: Practical Tools for Project/Trial Management *in-person*
Thursday, 30 April 2026, 9.30am to 12.30pm
OCTRU Workshop: How to identify required CRFs and develop fit for purpose CRFs (from protocol to CRFs) *in-person*
Tuesday, 16 June 2026, 10am to 12.30pm
OCTRU Workshop: How to identify required CRFs and develop fit for purpose CRFs (from protocol to CRFs) *in-person*
Wednesday, 25 November 2026, 10am to 12.30pm
OCTRU Training Bite: Audits & Audit Findings *online*
Wednesday, 28 January 2026, 10am to 11.30am
OCTRU Training Bite: Common findings from OCTRU Sponsor Package Reviews, DM12 reviews and database builds *online*
Wednesday, 11 February 2026, 11am to 12pm
OCTRU Training Bite: Trial Closure and Archiving *online*
Wednesday, 11 March 2026, 10am to 11am
OCTRU Training Bite: SIMS Overview - Setup and Initial Basic Configuration *online*
Thursday, 12 March 2026, 11am to 12pm
OCTRU Training Bite: Safety Oversight and Reporting *online*
Wednesday, 23 September 2026, 10am to 11.30am
Needs new date in Nov - OCTRU Training Bite: Grant Development and Costing for Trial Managers - what needs to go in *online*
Thursday, 01 January 2026, 10.02am to 10.03am
OCTRU Training Bite: Patient Information Sheets (PIS): Development of good PIS *online*
Tuesday, 03 November 2026, 10am to 11am