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The Aspirin Esomeprazole Chemoprevention Trial (AspECT) is to our knowledge one of the largest cancer prevention trials using aspirin and acid suppression in the world. In total 2557 patients with a common precancerous change in their oesophagus, called Barrett’s oesophagus, were followed up for an average of 9 years resulting in over 20,000 life-years of follow up. After informed written consent, patients were randomly allocated to four different combinations; Low acid suppression alone, High acid suppression alone, low acid suppression with 300mg aspirin and high acid suppression with 300mg aspirin. We wanted to see if we could prevent progression to local cancer/cancer in-situ (high grade dysplasia), invasive cancer or prevent death by all causes both cancer and non-cancer.
MSD Mediation Service
Building better workplace relationships and equipping people to manage conflict better.
New theory for spontaneous reporting of suspected adverse drug reactions to biological therapies
Adverse drug reactions, commonly known as side effects, place a significant burden on health services and account for patient deaths, disease, and extra costs in the UK and worldwide. This research is about the reporting of side effects of biologic medicines on patients.
UK Human Functional Genomics Initiative: Musculoskeletal Cluster
Our research will use genetics to improve our understanding and treatment of musculoskeletal diseases, such as osteoarthritis and carpal tunnel syndrome, which cause more years of disability and pain than any other disease class.
2022-2024 cohort
Find out about our 2022-2024 alumni.