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NEOPANC-01 is a window of opportunity study looking to assess gene expression in patients with resectable pancreatic cancer. It aims to evaluate the utility of whole transcriptome RNA sequencing as a potential biomarker for future window-of-opportunity trials that will assess existing and/or new treatments for pancreatic cancer. An understanding of the variability in the transcriptomic signature between biopsies will also inform power calculations for future studies. Lastly, the data generated will be available for use as historical controls for future studies. 2 sets of biopsy samples will be taken throughout the trial. Firstly during an endoscopic ultrasound procedure and then again, up to 6 weeks later, during the patients surgery to remove the cancer. Once all patients have been recruited, the mRNA from the samples will be sequenced and analysed. Further samples will also be taken at the same time points for storage into a biobank and for use in future research. This is a single site study opening at the Churchill Hospital looking to recruit 10 patients over 18 months.
Wiberg Group | Peripheral Nerve Research Lab
Translational research at the intersection of peripheral nerve surgery and laboratory science, working to develop better treatments for those living with nerve compression, nerve injury, and nerve pain.
Improving Wrist Injury Pathways (I-WIP)
Wrist injuries are a big and common problem for patients and the NHS, with around 70,000 patients a year in the UK going to hospitals with wrist pain after an injury and normal x-rays.
Dendrou Group | Immune Disease Multiomics
Our research aims to compare inflammatory diseases and immunological responses across tissues, over time and upon perturbation for translational benefit, leveraging multiomic technologies.
The CELLOS Study
Development of a core outcome set for children’s elective lower limb orthopaedic surgery
WHiTE-13 DECI
This study has been designed following a James Lind Alliance Patient and Public Research Priority Setting Partnership, which identified the following question as a key research priority: “What are the best treatments to prevent and treat confusion and delirium after surgery in adults with a broken bone in the leg?”
Public perceptions of health data sharing for AI Research: the PHAIR study
The aim of this study is to explore what the UK public think about sharing their health data to develop and test artificial intelligence (AI).
Fullerton Group | Translational Pharmacology
The Translational Pharmacology group focuses on the use of human experimental medicine studies to achieve scientific insight for patient benefit.
HIPCARE
With rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?
HIPCARE
With rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?
ODD SOCKS
A multi-centre prospective randomised superiority trial of conservative versus surgical treatment for displaced distal tibial fractures in children aged 8-15 years.