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NEOPANC-01 is a window of opportunity study looking to assess gene expression in patients with resectable pancreatic cancer. It aims to evaluate the utility of whole transcriptome RNA sequencing as a potential biomarker for future window-of-opportunity trials that will assess existing and/or new treatments for pancreatic cancer. An understanding of the variability in the transcriptomic signature between biopsies will also inform power calculations for future studies. Lastly, the data generated will be available for use as historical controls for future studies. 2 sets of biopsy samples will be taken throughout the trial. Firstly during an endoscopic ultrasound procedure and then again, up to 6 weeks later, during the patients surgery to remove the cancer. Once all patients have been recruited, the mRNA from the samples will be sequenced and analysed. Further samples will also be taken at the same time points for storage into a biobank and for use in future research. This is a single site study opening at the Churchill Hospital looking to recruit 10 patients over 18 months.
Public perceptions of health data sharing for AI Research: the PHAIR study
The aim of this study is to explore what the UK public think about sharing their health data to develop and test artificial intelligence (AI).
Fullerton Group | Translational Pharmacology
The Translational Pharmacology group focuses on the use of human experimental medicine studies to achieve scientific insight for patient benefit.
HIPCARE
With rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?
HIPCARE
With rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?
ODD SOCKS
A multi-centre prospective randomised superiority trial of conservative versus surgical treatment for displaced distal tibial fractures in children aged 8-15 years.
FORENSIC
OCTRU SITU
The clinical and cost-effectiveness of lumbar fusion surgery for patients with persistent, severe low back pain: Short: FusiOn veRsus bEst coNServatIve Care.
Progatzky Group | Peripheral glia and immunity
Our research aims to elucidate the role of peripheral glial cells in tissue health and disease.
BigBOSS
The Big BOSS Study- The British Orthopaedic Slipped Capital Femoral Epiphysis (SCFE) Surgery Study for Severe Stable Slips. A multi-centre prospective randomised superiority trial of an acute deformity correction versus pinning in-situ for severe stable SCFE in children.
ADOPT
Osteoporosis is a common bone disease that causes weaker bones that break after a fall and lead to chronic severe pain and life-changing complications. There are treatments available that strengthen bones and lower the chance of another fracture. Many hospitals have specialist teams dedicated to finding patients who have broken a bone to prevent the next fracture. We know breaking a bone in the spine, a spine fracture, is a critical sign of osteoporosis. However, most patients don't realise they have a spine fracture as they cause temporary back pain that is often ignored. We know that over three million people have scans that include the spine, for other reasons such as lung or bowel problems. Up to 1 in 20 scans could be showing there is a spine fracture. Currently, very few fractures are recognised or acted upon. This project will use an innovative Artificial Intelligence (AI) software that automatically looks at existing CT scans to find these spine fractures and brings them directly to the specialist team's attention, to see if the patient needs bone-strengthening lifestyle advice and medicines. We call this an 'AI-enabled spine fracture pathway'. We will show that using the pathway will improve patient health and reduce costs to hospitals using multiple methods.
Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network
Botnar
Creating a global atlas of the musculoskeletal system
Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network
Creating a global atlas of the musculoskeletal system
ROBUST
OCTRU RRIO SITU
Clinical effectiveness of an adolescent-specific strengthening programme, compared to usual care, for ambulant adolescents with spastic cerebral palsy (ROBUST trial): a parallel group randomised controlled trial.
SPELL
OCTRU RRIO SITU
Clinical effectiveness of a child-specific dynamic stretching programme, compared to usual care, for ambulant children with spastic cerebral palsy (SPELL trial): a parallel group randomised controlled trial.
Health Economics & Outcomes Research
Arthritis Botnar Orthopaedics and trauma Statistics and epidemiology
Our research aims to improve people's health and wellbeing by making the most efficient use of health and social care resources. To achieve this, we use real-world data and mathematical models to evaluate the costs and consequences of applying different interventions over a period of time, often the entire lifetime of patients.
GEKO
OCTRU SITU
Genicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management
UNDERStudy
Prospective randomised controlled trial comparing endoscopic decompression of the ulnar nerve at the cubital tunnel with open surgery.
Luo Group | Statistical genomics and computational immunology
We develop statistical methods and computational software to better understand the genetic contribution to immune-mediated traits.