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The EU-PEARL project will take a systematic approach that enables patient-focused, cross company collaborative platform trials.

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Biophysical determinants of cell fate decisions in skin inflammatory diseases

Neo-antigen challenge to uncover the formation and persistence of CD4 T resident memory cells in humans

Clinical and cost effectiveness of AI-enabled vertebral fracture identification Fracture Liaison Services (FLS)

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

Vaccine LEGACY – Applying a systems based approach to accelerate vaccine development

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

New pattern-recognition receptor signalling modalities in inflammation

Microbiome metabolites as immune checkpoints

Granulopoiesis: chromatin topology and associated functions

How does ageing influence intrinsic cartilage repair in osteoarthritis?

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

How inflammatory macrophages instruct innate effector responses in the tumour microenvironment?

Engineering Resolution – mRNA targeting of chronic inflammatory disease

Investigating cross-tissue and cross-disease immune mechanisms using single-cell/spatial multiomics & machine learning/AI-powered language learning tools

Mechanical force matters in T-cell activation

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

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Meet the NDORMS team

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EU-PEARL Project

Press release

Supported by

This project has received funding from the Innovative Medicines Initiative 2 Join Undertaking under grant agreement No 853966. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The total budget is 26M€ for a project duration of 42 months.

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