Dani Prieto-Alhambra

MD MSc(Oxf) PhD

Professor of Pharmaco- and Device Epidemiology

Theme Lead for Observational Research, Centre for Statistics in Medicine
NIHR Senior Research Fellow
Fellow of the International Society of Pharmaco-Epidemiology, FISPE

Real World Evidence, Pharmaco-epidemiology, Device Epidemiology

I am an epidemiologist using routinely collected health data to generate reliable evidence for improved patient care here at the Centre for Statistics in Medicine in NDORMS.

Through an NIHR Senior Research Fellowship, I am investigating the use, safety, effectiveness and cost of drugs and devices as used in usual practice conditions and amongst older people with complex health needs.

I lead Pharmaco- and Device Epidemiology research at NDORMS, and have experience designing, analysing and interpreting electronic medical records from around the world. I’ve worked on databases like the United Kingdom’s CPRD (formerly GPRD), Spain’s SIDIAP Database, Denmark’s Danish Health Registries, Italy’s HSD, and the Netherlands’ IPCI (Netherlands).

More recently, I have joined the European Health Data & Evidence Network EHDEN (www.ehden.eu) and the Observational Health Data Sciences and Informatics OHDSI (www.ohdsi.org) in an effort to accelerate and improve the quality of real world evidence internationally.

Key publications

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.
Journal article

Roca-Ayats N. et al, (2017), N engl j med, 376, 1794 - 1795
Mortality rates at 10 years after metal-on-metal hip resurfacing compared with total hip replacement in England: retrospective cohort analysis of hospital episode statistics.
Journal article

Kendal AR. et al, (2013), Bmj, 347
Primary hip replacement prostheses and their evidence base: systematic review of literature.
Journal article

Kynaston-Pearson F. et al, (2013), Bmj, 347
The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study.
Journal article

Bayliss LE. et al, (2017), Lancet, 389, 1424 - 1430
Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study.
Journal article

Abrahamsen B. et al, (2016), Bmj, 353

Recent publications

Comparative effectiveness of the BNT162b2 vs ChAdOx1 vaccine against Covid-19
xie J. et al, (2021)
Risk-benefit of unicompartmental (vs total) knee replacement for patients with multi-morbidity: a non-randomised study and novel approaches to minimise confounding
Journal article

Prats-Uribe A. et al, (2021), Hta journal
90-Day all-cause mortality can be predicted following a total knee replacement: an international, network study to develop and validate a prediction model.
Journal article

Williams RD. et al, (2021), Knee surg sports traumatol arthrosc
The association between smoking and the development of rheumatoid arthritis: a population-based case-control study.
Journal article

Sánchez-Campamà J. et al, (2021), Reumatol clin (engl ed), 17, 566 - 569
Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2: a cohort analysis
Prieto-Alhambra D. et al, (2021)
International impact of large multi-centre surgical trials of arthroscopic subacromial decompression
Smith JA. et al, (2021)
Bariatric surgery increases the rate of major fracture: self-controlled case series study in UK Clinical Practice Research Datalink.
Journal article

Robinson DE. et al, (2021), J bone miner res, 36, 2153 - 2161
Predicting Imminent Fractures in Patients With a Recent Fracture or Starting Oral Bisphosphonate Therapy: Development and International Validation of Prognostic Models.
Journal article

Khalid S. et al, (2021), J bone miner res, 36, 2162 - 2176
Unicompartmental compared with total knee replacement for patients with multimorbidities: a cohort study using propensity score stratification and inverse probability weighting.
Journal article

Prats-Uribe A. et al, (2021), Health technol assess, 25, 1 - 126
Association of Tramadol vs Codeine Prescription Dispensation With Mortality and Other Adverse Clinical Outcomes.
Journal article

Xie J. et al, (2021), Jama, 326, 1504 - 1515

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