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Findings reported in The American Journal of Pathology suggest specialized proresolving mediators may become therapeutics that alleviate chronic tendon inflammation

Image shows interleukin IL-1beta stimulated tendon cells isolated from a patient with a shoulder tendon tear incubated in media containing either vehicle, 10nM Lipoxin B4 (LXB4), or 10nM Resolvin E1 (RvE1). Tendon cells were stained for inflammatory molecules pSTAT-1 (green) or IL-6 (red). LXB4 or RvE1 treatments moderate the pro-inflammatory phenotype of tendon cells, reducing expression of pSTAT-1 and IL6.

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Proresolving Mediators LXB4 and RvE1 Regulate Inflammation in Stromal Cells from Patients with Shoulder Tendon Tears

 

 

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