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MEMOS
This is a mechanistic trial of Mifamurtide (MTP-PE) in patients with Metastatic and/or recurrent Osteosarcoma
INTACT
INtravenous Iron to Treat Anaemia in CriTical Care Survivors: a feasibility study
PACMEL
This is a randomised phase 2 study of paclitaxel with or without GSK1120212 or pazopanib in advanced wt BRAF melanoma
RHYTHM-I
This is a single centre trial involving Radiotherapy to see if outcomes can be improved in rectal cancer
DEBIOC
This is phase 1 multi-centre dose-escalating and safety study of AZD8931 in combination with Oxaliplatin and Capecitabine chemotherapy in patients with Oesophago-gastric adenocarcinoma.
PEMBLA
The PemBla trial is a parallel group, open label, multi-centre, randomised, phase I/II marker-lesion study of intravesical or intravenous pembrolizumab. The main study will be preceded by a single-institution safety run-in with intra-patient dose escalation of intravesical pembrolizumab performed in paired patient cohorts to confirm the safety and tolerability of intravesical pembrolizumab and the dose to be used in the randomised phase.
AIM-trial
This was a pragmatic, multi-centre, individually randomised controlled equivalence study with parallel prospective economic evaluation comparing close contact casting technique (CCC) to open reduction and Internal Fixation (ORIF) for patients over 60 years of age with unstable ankle fractures.
SARAH
This trial contacted 490 people who had problems with their hands and wrists as a result of Rheumatoid Arthritis (RA). They then either received usual care (between 1 and 3 sessions of advice with a hand therapist) or the SARAH exercise programme (6 sessions of supervised exercises with a hand therapist).
CHOP-OR
This is a single arm multi-centre NCRI feasibility study of CHOP combined with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter’s syndrome.
CAMELLIA: A Phase I dose escalation trial of the Humanized Anti-CD47 Monoclonal Antibody Hu5F9-G4 in Haematological Malignancies
This is a multi-centre, non-randomised trial of an antibody in patients with acute myeloid leukaemia (AML) or High Risk Myelodysplastic Syndrome (MDS).
LECTINS
A feasibility study to investigate the use of fluorescent lectins to identify dysplasia and cancer during endoscopy and surgery
Oncology Clinical Trials Office (OCTO)
Founded in 2002 the Oncology Clinical Trials Office (OCTO) began as a unit running large phase III trials in adjuvant colorectal cancer. We have since developed our trials portfolio to concentrate on the practical application of high quality clinical research into innovative and effective early detection, precision prevention and early phase cancer trials
Trauma and Emergency Care Group
We run a number of clinical trials in orthopaedic trauma and aim to inform best practice in the field, as well as the National Institute for Health and Care Excellence (NICE) guidelines. The Trauma and Emergency Care group is situated at the Kadoorie Critical Care Research Centre located at the John Radcliffe Hospital.
Experimental Medicine and Rheumatology
Our group delivers innovative rheumatology and experimental medicine clinical trials, combining deep expertise in inflammatory and musculoskeletal diseases with advanced experimental medicine approaches. We design and run studies across the clinical trial pathway, from early mechanistic and biomarker-driven investigations to later-phase and pragmatic rheumatology trials, with the aim of improving understanding of disease biology, accelerating the development of effective therapies and optimising treatment strategy in routine care.
Surgical Intervention Trials Unit (SITU-NDS)
The University of Oxford Surgical Intervention Trials Unit (SITU) represents a collaboration between the Nuffield Department of Surgical Sciences (NDS) and the Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences (NDORMS). SITU is a dedicated team of surgical investigators offering expert trial management support and serving as a training and development hub for surgical trialists across the UK. Recognized as one of nine UK Royal College of Surgeons-endorsed clinical trial centres, SITU supports trials spanning all surgical specialties, from urology to orthopaedics.
Gastroenterology Trials Group (GTU)
The Gastroenterology and Hepatology Clinical Trials’ group was established as an integral part of the Translational Gastroenterology Unit in 2009. It provides the resource for clinical trials in Gastroenterology so that patients have access to the newest potential treatments, scientists have a platform to translate target discovery into practice and that Oxford is seen to make a substantial contribution to drug development in Gastroenterology.
Centre for Statistics in Medicine (CSM)
Making a Difference in Health Care Research. Oxford. The Centre for Statistics in Medicine collaborates in health care research, conducts applied statistical research, and runs training courses/workshops for health care workers and statisticians.
WHiTE Study
A Comprehensive Cohort Study of Patients with Fracture of the Proximal Femur.