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Progatzky Group | Peripheral glia and immunity
Our research aims to elucidate the role of peripheral glial cells in tissue health and disease.
BigBOSS
The Big BOSS Study- The British Orthopaedic Slipped Capital Femoral Epiphysis (SCFE) Surgery Study for Severe Stable Slips. A multi-centre prospective randomised superiority trial of an acute deformity correction versus pinning in-situ for severe stable SCFE in children.
ADOPT
Osteoporosis is a common bone disease that causes weaker bones that break after a fall and lead to chronic severe pain and life-changing complications. There are treatments available that strengthen bones and lower the chance of another fracture. Many hospitals have specialist teams dedicated to finding patients who have broken a bone to prevent the next fracture. We know breaking a bone in the spine, a spine fracture, is a critical sign of osteoporosis. However, most patients don't realise they have a spine fracture as they cause temporary back pain that is often ignored. We know that over three million people have scans that include the spine, for other reasons such as lung or bowel problems. Up to 1 in 20 scans could be showing there is a spine fracture. Currently, very few fractures are recognised or acted upon. This project will use an innovative Artificial Intelligence (AI) software that automatically looks at existing CT scans to find these spine fractures and brings them directly to the specialist team's attention, to see if the patient needs bone-strengthening lifestyle advice and medicines. We call this an 'AI-enabled spine fracture pathway'. We will show that using the pathway will improve patient health and reduce costs to hospitals using multiple methods.
Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network
Creating a global atlas of the musculoskeletal system
Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network
Creating a global atlas of the musculoskeletal system
Health Economics & Outcomes Research
Our research aims to improve people's health and wellbeing by making the most efficient use of health and social care resources. To achieve this, we use real-world data and mathematical models to evaluate the costs and consequences of applying different interventions over a period of time, often the entire lifetime of patients.
UNDERStudy
Prospective randomised controlled trial comparing endoscopic decompression of the ulnar nerve at the cubital tunnel with open surgery.
Luo Group | Statistical genomics and computational immunology
We develop statistical methods and computational software to better understand the genetic contribution to immune-mediated traits.
Johnson Group | Microbiome and Multi-omics
Applying multi-omic and computational genomic approaches to understand the molecular basis of host-microbiome interactions
Theologis Group | Paediatric Orthopaedics
Cerebral palsy is the most common cause of childhood disability. The Theologis Group will run the first ever set of trials into cerebral palsy, to address the issues that matter the most to patients and provide evidence-based solutions.
PRePPeD
PRePPeD – Physiotherapy Rehabilitation Post Patellar Dislocation
DRAFT3 – CASP
This trial aims to compare two treatment methods that are currently standard care for treating wrist fractures. There are a large number of wrist fractures every year in the UK and by comparing the clinical and cost effectiveness of the treatments, this could help save money for the NHS.