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Four investigators based at the Botnar Research Centre, NDORMS have been recently awarded National Institute for Health Research (NIHR) fellowships to further our understanding of a variety of musculoskeletal conditions and develop better methodology to support medical research.

Lead researchers (from left to right): Professor Daniel Prieto-Alhambra, Maria Dudereva, Ioana Marian, Simon Wood

Neo-antigen challenge to uncover the formation and persistence of CD4 T resident memory cells in humans

Investigating the tissue response to a novel knee ligament implant

Clinical and cost effectiveness of AI-enabled vertebral fracture identification Fracture Liaison Services (FLS)

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

Vaccine LEGACY – Applying a systems based approach to accelerate vaccine development

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

New pattern-recognition receptor signalling modalities in inflammation

Microbiome metabolites as immune checkpoints

Granulopoiesis: chromatin topology and associated functions

How does ageing influence intrinsic cartilage repair in osteoarthritis?

Resident memory B cell responses in the lung; immunity against pulmonary pathogens

How inflammatory macrophages instruct innate effector responses in the tumour microenvironment?

Engineering Resolution – mRNA targeting of chronic inflammatory disease

Investigating cross-tissue and cross-disease immune mechanisms using single-cell/spatial multiomics & machine learning/AI-powered language learning tools

Mechanical force matters in T-cell activation

Relationship between Tumour microenvironment and atherosclerotic cardiovascular disease during immunotherapy

Harnessing human genomic, transcriptomic and proteomic data to identify novel therapeutic targets

How do secreted phospho-proteins dictate fibroblast-neutrophil crosstalk in treatment resistant inflammatory bowel disease?

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Meet the team

Funded by

National Institute for Health and Care Research logo

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Our Groups, Centres and Units

Our Research Themes

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Our Programme Grants

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