Model-based trial design for more efficient phase I trials

Nirmatrelvir-ritonavir versus usual care in at-risk adults with early SARS-CoV-2 infection in the UK, 2022-23: virological and immunological results of an open-label randomised trial (PANORAMIC).

Lowe DM. et al, (2027), Lancet Microbe

Multi-objective optimisation of 3D-printed multilayer TPMS osteochondral scaffolds for enhanced mechanical and biological performance

Xu Y. et al, (2026), Virtual and Physical Prototyping, 21

Subharmonics are not an infallible safety metric for cavitation dynamics.

Wu Q. et al, (2026), Int J Hyperthermia, 43

Assessing the Importance of Variation in Diagnostic Coding Among the Three Countries in the UK Biobank.

Clifton L. et al, (2026), Learn Health Syst, 10

Bimekizumab treatment in patients with active psoriatic arthritis and prior inadequate response to tumour necrosis factor inhibitors: 52-week safety and efficacy from the phase III BE COMPLETE study and its open-label extension BE VITAL

Coates LC. et al, (2026), RMD Open, 20, e043855 - e043855

Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature.

Scherlinger M. et al, (2026), J Transl Autoimmun, 12

Real-world obesity prevalence and history in 79 271 patients receiving systemic anticancer therapy across 13 cancer types in England (2013-2023).

Perletta V. et al, (2026), ESMO Real World Data Digit Oncol, 12

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.

Alsaleh G. et al, (2026), Aging Cell, 25

Recent advances in biomaterials and structural design of 3D printed multiphasic scaffolds for osteochondral regeneration

Xu Y. et al, (2026), Materials Science and Engineering: R: Reports, 170, 101210 - 101210

Experimental characterisation of coefficient of friction at bone-implant interface

Min X. et al, (2026), Frontiers in Mechanical Engineering

Prevalence, trends, and determinants of early-onset type 2 diabetes in northwest China: a sex-stratified analysis of ∼10 million community-dwelling population.

Wang J. et al, (2026), Diabetes Res Clin Pract

Prevalence of foot/ankle osteoarthritis and pain in retired male professional footballers compared to general population male controls: a cross-sectional study.

Thanoon AA. et al, (2026), Rheumatology (Oxford)

Quantifying 3D live-cell membrane dynamics using dynamic metal-induced energy transfer spectroscopy (dynaMIET).

Gallea JI. et al, (2026), Sci Adv, 12

PD-1 signaling and PD-1 blockade-mediated tumor control are established at microvillar T cell contacts.

Jenkins E. et al, (2026), Sci Immunol, 11

Pain outcomes from past patients after total knee arthroplasty: regression tree analysis to generate insights for new patients

Revaz M. et al, (2026)

Past patients’ long-term experiences with complications, revision, and contralateral knee replacement after primary TKA can meaningfully inform the journey of new patients

Revaz M. et al, (2026)

Comment on: Exploring the effects of GLP-1 receptor agonists in fibromyalgia: a propensity-matched real-world cohort using the TriNetX research platform: Reply

Eshak N. et al, (2026), Rheumatology

Ultrasound-mediated focal serotonin delivery causally modulates motivation in primates

Winiarski S. et al, (2026)

Severe menstrual pain is not normal: adolescent dysmenorrhoea as a marker of future chronic pain

Poli-Neto OB. et al, (2026), Revista Brasileira de Ginecologia e Obstetrícia, 48

Mezigdomide reverses T-cell exhaustion through degradation of IKZF1/IKZF3 and reinvigoration of cytokine production pathways.

Chiu H. et al, (2026), Blood

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