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A new study published in the Journal of Experimental Medicine reveals how IL-10 and PGE2 work together to prevent inflammatory tissue damage and maintain a healthy gut balance

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The new study shows the IL-10-PGE2 axis ensures macrophages are effective at killing potentially harmful bacteria

Dakin Group | Soft Tissue Joint Disease

Botnar Inflammation biology Orthopaedics and trauma Tissue remodelling and regeneration

The Dakin Group undertakes translational research focusing on identifying the cellular basis of inflammatory fibrotic musculoskeletal diseases, with research programmes on tendinopathy and frozen shoulder. Understanding the cellular and molecular basis of these diseases will inform new therapeutic approaches targeting tissue resident stromal cells of the joint, to promote resolution of chronic inflammation and fibrosis.

MEET FIONA

  • Fiona Powrie FRS
    Fiona Powrie FRS

    Professor of Musculoskeletal Sciences and Director of the Kennedy Institute

FUNDED BY

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 Fondation Louis-Jeantet

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Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2
Journal of Experimental Medicine

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