Fiona Powrie FRS

• Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

  Schwerd T. et al, (2017), Gut, 66, 1060 - 1073

• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

  West NR. et al, (2017), Nature medicine, 23, 579 - 589

• Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

  Fenton TM. et al, (2017), Mucosal immunology, 10, 624 - 634

• Th1 and Innate Lymphoid Cells accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.

  Gwela A. et al, (2017), Journal of Crohn's & colitis

• Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

  Chen HH. et al, (2017), The Journal of allergy and clinical immunology, 139, 607 - 620.e15

• Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.

  Ilott NE. et al, (2016), The ISME journal, 10, 2389 - 2404

• T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

  Krausgruber T. et al, (2016), Nature communications, 7

• Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes.

  Lochmatter C. et al, (2016), Scientific reports, 6

• RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

  de Wit J. et al, (2016), The Journal of allergy and clinical immunology, 137, 960 - 963

• CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

  Fergusson JR. et al, (2016), Mucosal Immunology, 9, 401 - 413

• CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.

  Arnold IC. et al, (2016), Mucosal Immunology, 9, 352 - 363

• ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.

  Pearson C. et al, (2016), eLife, 5

• Immunotherapy Not Working? Check Your Microbiota.

  West NR. and Powrie F., (2015), Cancer cell, 28, 687 - 689

• Emerging cytokine networks in colorectal cancer.

  West NR. et al, (2015), Nature reviews. Immunology, 15, 615 - 629

• MICROBIOME. Microbiota RORgulates intestinal suppressor T cells.

  Hegazy AN. and Powrie F., (2015), Science (New York, N.Y.), 349, 929 - 930

• Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription.

  Alasoo K. et al, (2015), Scientific reports, 5

• Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.

  Griseri T. et al, (2015), Immunity, 43, 187 - 199

• Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

  Taylor JC. et al, (2015), Nature genetics, 47, 717 - 726

• Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis.

  Arnold IC. et al, (2015), Vaccine, 33, 1808 - 1814

• Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

  Hale C. et al, (2015), PloS one, 10

• Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis

  Arnold IC. et al, (2015), Vaccine, 33, 1808 - 1814

• The role of FoxP3(+) regulatory T-cells in psoriasiform skin disease

  Adelmann K. et al, (2014), IMMUNOLOGY, 143, 175 - 175

• Induced pluripotent stem cell derived macrophage is a useful cellular system to study human restricted intestinal pathogen Salmonella Typhi

  Hale C. et al, (2014), IMMUNOLOGY, 143, 110 - 110

• Human ILC-T-cell interactions in inflammatory bowel disease

  Schaupp A-L. et al, (2014), IMMUNOLOGY, 143, 103 - 103

• A GM-CSF eosinophil axis promotes IL-23-mediated chronic intestinal inflammation

  Arnold IC. et al, (2014), IMMUNOLOGY, 143, 106 - 106

• The role of FoxP3+regulatory T cells in psoriasiform skin disease

  Adelmann K. et al, (2014), EXPERIMENTAL DERMATOLOGY, 23, 8 - 8

• The alarmin IL-33 promotes regulatory T-cell function in the intestine.

  Schiering C. et al, (2014), Nature, 513, 564 - 568

• Gut reactions: immune pathways in the intestine in health and disease

  Powrie F., (2014), FEBS JOURNAL, 281, 10 - 10

• IN-VITRO SUPRESSION OF TH17 RESPONSES IN INFLAMMATORY ARTHRITIS PATIENTS USING SMALL MOLECULE ROR-GAMMA-T INHIBITORS

  Al-Mossawi MH. et al, (2014), ANNALS OF THE RHEUMATIC DISEASES, 73, 357 - 357

• A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

  Steward-Tharp SM. et al, (2014), Blood, 123, 2978 - 2987

• Polyfunctionality of human gut-homing CD4 T cells

  Hegazy AN. et al, (2014), JOURNAL OF CROHNS & COLITIS, 8, S78 - S78

• Innate lymphoid cells accumulate in IBD

  Geremia A. et al, (2014), JOURNAL OF CROHNS & COLITIS, 8, S1 - S1

• Dendritic cell subsets in the maintenance of gut health and response to bioactives

  Schulthess J. et al, (2014), JOURNAL OF CROHNS & COLITIS, 8, S98 - S98

• SUPPRESSION OF IN-VITRO TYPE-17 RESPONSES IN SPA PATIENTS USING SMALL MOLECULE ROR-gamma T INHIBITORS

  De Wit J. et al, (2014), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 32, 811 - 811

• Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease

  Avitzur Y. et al, (2014), Gastroenterology, 146, 1028 - 1039

• IL-23 production by CD11c(+) mononuclear phagocytes drives chronic Helicobacter hepaticus-induced intestinal inflammation

  Arnold IC. et al, (2013), IMMUNOLOGY, 140, 202 - 203

• Expression and regulation of the TGF-beta-activating integrin alpha(v)beta(8) on human dendritic cells

  Fenton TM. et al, (2013), IMMUNOLOGY, 140, 147 - 148

• Controlling the frontier: regulatory T-cells and intestinal homeostasis.

  Bollrath J. and Powrie FM., (2013), Seminars in immunology, 25, 352 - 357

• EARLY AND NON-REVERSIBLE DECREASE OF CD161++/MUCOSAL ASSOCIATED INVARIANT T CELLS IN HIV INFECTION

  Cosgrove C. et al, (2013), JOURNAL OF INFECTION, 67, 342 - 343

• Immunology. Feed your Tregs more fiber.

  Bollrath J. and Powrie F., (2013), Science (New York, N.Y.), 341, 463 - 464

• Regulatory T cells and immune tolerance in the intestine.

  Harrison OJ. and Powrie FM., (2013), Cold Spring Harbor perspectives in biology, 5

• Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.

  Kirchberger S. et al, (2013), The Journal of experimental medicine, 210, 917 - 931

• Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.

  Knosp CA. et al, (2013), Journal of immunology (Baltimore, Md. : 1950), 190, 3235 - 3245

• CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.

  Barnes MJ. et al, (2013), Mucosal Immunology, 6, 324 - 334

• CD4(+) T-cell subsets in intestinal inflammation.

  Shale M. et al, (2013), Immunological reviews, 252, 164 - 182

• Innate lymphoid cells--a proposal for uniform nomenclature.

  Spits H. et al, (2013), Nature reviews. Immunology, 13, 145 - 149

• Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.

  Beverley P. et al, (2013), Vaccine, 31, 1086 - 1093

• Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.

  Cosgrove C. et al, (2013), Blood, 121, 951 - 961

• Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

  Griseri T. et al, (2012), IMMUNITY, 37, 1116 - 1129

• Gender equality: is it real?

  Simon K. et al, (2012), European journal of immunology, 42, 3095 - 3096

• The role of innate lymphoid cells in colitis-associated cancer

  Kirchberger S. et al, (2012), IMMUNOLOGY, 137, 100 - 100

• Role of dendritics cells during IBD

  Schulthess J. et al, (2012), IMMUNOLOGY, 137, 534 - 535

• Mononuclear phagocytes in steady-state and colitis

  Arnold IC. et al, (2012), IMMUNOLOGY, 137, 533 - 533

• Innate lymphoid cells in models of IBD

  Pearson C. et al, (2012), IMMUNOLOGY, 137, 222 - 223

• IL-1 mediates intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

  Coccia M. et al, (2012), IMMUNOLOGY, 137, 532 - 532

• IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.

  Coccia M. et al, (2012), The Journal of experimental medicine, 209, 1595 - 1609

• Immunology: Malnutrition promotes rogue bacteria.

  Izcue A. and Powrie F., (2012), Nature, 487, 437 - 439

• Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

  Boulard O. et al, (2012), The Journal of experimental medicine, 209, 1309 - 1324

• Microbiota, disease, and back to health: a metastable journey.

  Blumberg R. and Powrie F., (2012), Science translational medicine, 4

• Lymphoid microenvironments and innate lymphoid cells in the gut.

  Pearson C. et al, (2012), Trends in immunology, 33, 289 - 296

• Gut reactions: immune pathways in the intestine in health and disease.

  Powrie F., (2012), EMBO molecular medicine, 4, 71 - 74

• Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8 ⁺ T cells

  Walker LJ. et al, (2012), Blood, 119, 422 - 433

• Re-establishing immunological self-tolerance in autoimmune disease.

  Sakaguchi S. et al, (2012), Nature medicine, 18, 54 - 58

• Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.

  Walker LJ. et al, (2012), Blood, 119, 422 - 433

• SOCS2 regulates Foxp3+inducible Treg stability

  Knosp CA. et al, (2011), IMMUNOLOGY, 135, 48 - 48

• Interleukin 7 signaling on DCs regulates the CD 4 T cell niche

  Fewkes N. et al, (2011), IMMUNOLOGY, 135, 127 - 127

• Induction of Interleukin-10 expression by the commensal flora

  Bollrath J. et al, (2011), IMMUNOLOGY, 135, 125 - 125

• Genetic regulation of early inflammatory responses shapes a pro-carcinogenic microenvironment in a Helicobacter hepaticus-driven innate colitis model

  Kirchberger S. et al, (2011), IMMUNOLOGY, 135, 105 - 105

• Exacerbated hematopoietic stem and progenitor cell activity during intestinal inflammation

  Griseri T. and Powrie F., (2011), IMMUNOLOGY, 135, 175 - 175

• Cytokine requirements in models of inflammatory bowel disease

  Pearson C. et al, (2011), IMMUNOLOGY, 135, 119 - 119

• CX(3)CR1(int) lamina propria cells accumulate during multiple models of colitis and can be distinguished from CX(3)CR1(hi) lamina propria cells by Ly6C expression

  Mathisen S. et al, (2011), IMMUNOLOGY, 135, 97 - 97

• A hyper-IgE syndrome mouse model

  Steward-Tharp S. et al, (2011), IMMUNOLOGY, 135, 174 - 174

• Gut reactions: Immune pathways in the intestine in health and disease

  Powrie F., (2011), CYTOKINE, 56, 1 - 1

• Intestinal homeostasis and its breakdown in inflammatory bowel disease.

  Maloy KJ. and Powrie F., (2011), Nature, 474, 298 - 306

• IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease.

  Geremia A. et al, (2011), The Journal of experimental medicine, 208, 1127 - 1133

• Regulation of haematopoiesis during colitis

  Griseri T. and Powrie F., (2010), IMMUNOLOGY, 131, 183 - 184

• Mouse IBD models reveal distinct pathogenic and protective roles of MyD88 signalling in epithelial cells and leukocytes

  Asquith MJ. et al, (2010), IMMUNOLOGY, 131, 178 - 178

• Interleukin-23 drives intestinal inflammation through direct activity on T cells

  Schiering C. et al, (2010), IMMUNOLOGY, 131, 56 - 56

• Characterization of the role of IL-10 in resolution from intestinal inflammation

  Szabady R. et al, (2010), IMMUNOLOGY, 131, 186 - 186

• A genetic interval confers protection from colitis and colitis-associated cancer in a model of bacteria-induced colon cancer

  Kirchberger S. et al, (2010), IMMUNOLOGY, 131, 144 - 145

• Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease.

  Asquith MJ. et al, (2010), Gastroenterology, 139, 519 - 529.e2

• Interleukin-23 drives intestinal inflammation through direct activity on T cells.

  Ahern PP. et al, (2010), Immunity, 33, 279 - 288

• An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.

  Asquith M. and Powrie F., (2010), The Journal of experimental medicine, 207, 1573 - 1577

• Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells.

  Laffont S. et al, (2010), European journal of immunology, 40, 1877 - 1883

• Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

  Durant L. et al, (2010), Immunity, 32, 605 - 615

• E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.

  Siddiqui KR. et al, (2010), Immunity, 32, 557 - 567

• OX40 is required for regulatory T cell-mediated control of colitis.

  Griseri T. et al, (2010), The Journal of experimental medicine, 207, 699 - 709

• Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

  Buonocore S. et al, (2010), Nature, 464, 1371 - 1375

• TLR2-independent induction and regulation of chronic intestinal inflammation.

  Boulard O. et al, (2010), European journal of immunology, 40, 516 - 524

• Fiona Powrie: Gut diplomacy. Interview by Amy Maxmen.

  Powrie F., (2010), The Journal of experimental medicine, 207, 4 - 5

• Immunology: Dendritic-cell genealogy.

  Laffont S. and Powrie F., (2009), Nature, 462, 732 - 733

• Regulatory T cells reinforce intestinal homeostasis.

  Barnes MJ. and Powrie F., (2009), Immunity, 31, 401 - 411

• Mouse models of intestinal inflammation as tools to understand the pathogenesis of inflammatory bowel disease.

  Uhlig HH. and Powrie F., (2009), European journal of immunology, 39, 2021 - 2026

• Hybrid Treg cells: steel frames and plastic exteriors.

  Barnes MJ. and Powrie F., (2009), Nature immunology, 10, 563 - 564

• Regulatory mechanisms in graft-versus-host responses.

  Edinger M. et al, (2009), Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 15, 2 - 6

• Regulatory Mechanisms in Graft-versus-Host Responses

  Edinger M. et al, (2009), Biology of Blood and Marrow Transplantation, 15, 2 - 6

• Regulatory lymphocytes and intestinal inflammation.

  Izcue A. et al, (2009), Annual review of immunology, 27, 313 - 338

• The interleukin-23 axis in intestinal inflammation.

  Ahern PP. et al, (2008), Immunological reviews, 226, 147 - 159

• Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis.

  Toms C. et al, (2008), Immunology, 125, 302 - 312

• Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.

  Jaensson E. et al, (2008), The Journal of experimental medicine, 205, 2139 - 2149

• Dendritic cells in intestinal immune regulation

  Coombes JL. and Powrie F., (2008), NATURE REVIEWS IMMUNOLOGY, 8, 435 - 446

• Dendritic cells in intestinal immune regulation.

  Coombes JL. and Powrie F., (2008), Nature reviews. Immunology, 8, 435 - 446

• Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.

  Izcue A. et al, (2008), Immunity, 28, 559 - 570

• Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.

  Izcue A. and Powrie F., (2008), Immunology, 123, 6 - 10

• Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.

  Willoughby JE. et al, (2007), Journal of immunology (Baltimore, Md. : 1950), 179, 6836 - 6844

• The IL23 axis plays a key role in the pathogenesis of IBD.

  McGovern D. and Powrie F., (2007), Gut, 56, 1333 - 1336

• Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells.

  Stepankova R. et al, (2007), Inflammatory bowel diseases, 13, 1202 - 1211

• Emerging challenges in regulatory T cell function and biology.

  Sakaguchi S. and Powrie F., (2007), Science (New York, N.Y.), 317, 627 - 629

• A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.

  Coombes JL. et al, (2007), The Journal of experimental medicine, 204, 1757 - 1764

• Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology

  Uhlig HH. et al, (2007), EUROPEAN JOURNAL OF PEDIATRICS, 166, 279 - 279

• Regulatory T Cells

  Read S. et al, (2006), 119 - 131

• FOXP3+ regulatory T cells: Current controversies and future perspectives.

  Banham AH. et al, (2006), European journal of immunology, 36, 2832 - 2836

• Eosinophilic bowel disease controlled by the BB rat-derived lymphopenia/Gimap5 gene.

  Cousins L. et al, (2006), Gastroenterology, 131, 1475 - 1485

• Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis.

  Uhlig HH. et al, (2006), Journal of immunology (Baltimore, Md. : 1950), 177, 5852 - 5860

• Interleukin-23 drives innate and T cell-mediated intestinal inflammation.

  Hue S. et al, (2006), The Journal of experimental medicine, 203, 2473 - 2483

• IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

  Kullberg MC. et al, (2006), The Journal of experimental medicine, 203, 2485 - 2494

• Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.

  Read S. et al, (2006), Journal of immunology (Baltimore, Md. : 1950), 177, 4376 - 4383

• Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.

  Izcue A. et al, (2006), Immunological reviews, 212, 256 - 271

• Untitled - Response

  Banham AH. and Powrie F., (2006), EUROPEAN JOURNAL OF IMMUNOLOGY, 36, 246 - 246

• Improved immune recognition through antigen targeting to the mannose receptor

  McKenzie EJ. et al, (2005), IMMUNOLOGY, 116, 17 - 17

• Comments on exclusion and cost [4]

  Powrie F., (2005), Pharmaceutical Journal, 275

• Fueling regulation: IL-2 keeps CD4+ Treg cells fit.

  Maloy KJ. and Powrie F., (2005), Nature immunology, 6, 1071 - 1072

• Essential role for CD103 in the T cell-mediated regulation of experimental colitis.

  Annacker O. et al, (2005), The Journal of experimental medicine, 202, 1051 - 1061

• The role of mucosal T lymphocytes in regulating intestinal inflammation.

  Uhlig HH. and Powrie F., (2005), Springer seminars in immunopathology, 27, 167 - 180

• Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level.

  Roncador G. et al, (2005), European journal of immunology, 35, 1681 - 1691

• Regulatory T cells and intestinal homeostasis.

  Coombes JL. et al, (2005), Immunological reviews, 204, 184 - 194

• A role of bacteria in inflammatory bowel disease evoked in animal models

  Strus M. et al, (2005), Gastroenterologia Polska, 12, 15 - 20

• T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.

  Fahlén L. et al, (2005), The Journal of experimental medicine, 201, 737 - 746

• Prenatal tolerance--a role for regulatory T cells?

  Izcue A. and Powrie F., (2005), European journal of immunology, 35, 379 - 382

• Final discussion

  Jewell DP. et al, (2004), Novartis Foundation Symposium, 263, 211 - 218

• Discussion

  Meddings JB. et al, (2004), Novartis Foundation Symposium, 263, 145 - 150

• Discussion

  Ghosh S. et al, (2004), Novartis Foundation Symposium, 263, 174 - 178

• Regulatory T cells.

  Thompson C. and Powrie F., (2004), Current opinion in pharmacology, 4, 408 - 414

• Is cod liver oil at risk? (multiple letters) [5]

  Powrie F. and Shotter PJ., (2004), Pharmaceutical Journal, 272

• Homing of intestinal immune cells.

  Uhlig HH. et al, (2004), Novartis Foundation symposium, 263, 179 - 218

• Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease.

  Powrie F. and Uhlig H., (2004), Novartis Foundation symposium, 263, 164 - 218

• Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses.

  Uhlig HH. and Powrie F., (2003), The Journal of clinical investigation, 112, 648 - 651

• Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses

  Uhlig HH. and Powrie F., (2003), JOURNAL OF CLINICAL INVESTIGATION, 112, 648 - 651

• Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.

  Asseman C. et al, (2003), Journal of immunology (Baltimore, Md. : 1950), 171, 971 - 978

• Interleukin-10 in the regulation of T cell-induced colitis.

  Annacker O. et al, (2003), Journal of autoimmunity, 20, 277 - 279

• Anti-interleukin 12 antibody prevents colitis in a murine T cell transfer model of inflammatory bowel disease

  Singh B. and Powrie F., (2003), BRITISH JOURNAL OF SURGERY, 90, 637 - 638

• Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells.

  Mottet C. et al, (2003), Journal of immunology (Baltimore, Md. : 1950), 170, 3939 - 3943

• Regulating the regulators

  Powrie F. and Maloy KJ., (2003), SCIENCE, 299, 1030 - 1031

• Immunology. Regulating the regulators.

  Powrie F. and Maloy KJ., (2003), Science (New York, N.Y.), 299, 1030 - 1031

• Control of immune pathology by regulatory T cells.

  Powrie F. et al, (2003), Novartis Foundation symposium, 252, 92 - 114

• CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.

  Maloy KJ. et al, (2003), The Journal of experimental medicine, 197, 111 - 119

• Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens.

  Golgher D. et al, (2002), European journal of immunology, 32, 3267 - 3275

• CTLA-4 expression on antigen-specific cells but not IL-10 secretion is required for oral tolerance.

  Fowler S. and Powrie F., (2002), European journal of immunology, 32, 2997 - 3006

• CD4+CD25+cells reverse established colitis in the CD4+CD45RBhigh adoptive transfer model of colitis.

  Mottet C. et al, (2002), CLINICAL IMMUNOLOGY, 103, S91 - S91

• Homeostasis of intestinal immune regulation.

  Annacker O. and Powrie F., (2002), Microbes and infection, 4, 567 - 574

• Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

  Jones E. et al, (2002), Cancer immunity, 2

• Depletion of CD25+ regulatory cells results in suppression of melanomagrowth and induction of autoreactivity in mice

  Jones E. et al, (2002), Cancer Immunity, 5, 1 - 12

• Immune therapy in inflammatory bowel disease and models of colitis.

  Singh B. et al, (2001), The British journal of surgery, 88, 1558 - 1569

• Regulatory T cells in the control of immune pathology.

  Maloy KJ. and Powrie F., (2001), Nature immunology, 2, 816 - 822

• Control of intestinal inflammation by regulatory T cells.

  Singh B. et al, (2001), Immunological reviews, 182, 190 - 200

• CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

  Malmström V. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 6972 - 6981

• Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells.

  Read S. and Powrie F., (2001), Current protocols in immunology, Chapter 15, Unit - 15.13

• The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor.

  Lüttichau HR. et al, (2001), European journal of immunology, 31, 1217 - 1220

• Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.

  Stephens LA. et al, (2001), European journal of immunology, 31, 1247 - 1254

• Anti-OX40Ligand treatment as a novel therapeutic strategy in a murine model of colitis

  Singh B. et al, (2001), GASTROENTEROLOGY, 120, A685 - A685

• The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.

  Lucas AD. et al, (2001), The American journal of pathology, 158, 855 - 866

• IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.

  Hara M. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 3789 - 3796

• Immature dendritic cells induce alternative CD4(+) T-cell responses in vivo.

  Suri RM. et al, (2001), Transplantation proceedings, 33

• Control of experimental inflammatory bowel disease by regulatory T cells.

  Asseman C. et al, (2000), American journal of respiratory and critical care medicine, 162, S185 - S189

• Control of experimental inflammatory bowel disease by regulatory T cells

  Asseman C. et al, (2000), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 162, S185 - +

• Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.

  Read S. et al, (2000), The Journal of experimental medicine, 192, 295 - 302

• Regulatory T cells and inflammatory bowel disease.

  Groux H. and Powrie F., (1999), Immunology today, 20, 442 - 445

• An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.

  Asseman C. et al, (1999), The Journal of experimental medicine, 190, 995 - 1004

• The role of T cell subsets in hepatic inflammation in the scid model of colitis

  Singh B. et al, (1999), JOURNAL OF PATHOLOGY, 189, 19A - 19A

• The role of IL-10 in inflammatory bowel disease: "of mice and men".

  Leach MW. et al, (1999), Toxicologic pathology, 27, 123 - 133

• Control of immune pathology by IL-10-secreting regulatory T cells.

  Fowler S. and Powrie F., (1999), Springer seminars in immunopathology, 21, 287 - 294

• Control of immune pathology by regulatory T cells.

  Mason D. and Powrie F., (1998), Current opinion in immunology, 10, 649 - 655

• CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro.

  Read S. et al, (1998), European journal of immunology, 28, 3435 - 3447

• Interleukin 10 is a growth factor for a population of regulatory T cells.

  Asseman C. and Powrie F., (1998), Gut, 42, 157 - 158

• Induction of CD4+ T-cell responses by dendritic cells in vivo

  Suri RM. et al, (1998), JOURNAL OF LEUKOCYTE BIOLOGY, 32 - 32

• CD4+ T-cells in the regulation of inflammatory responses in the intestine.

  Powrie F. et al, (1997), Research in immunology, 148, 576 - 581

• Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus.

  Cahill RJ. et al, (1997), Infection and immunity, 65, 3126 - 3131

• A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

  Powrie F. et al, (1996), The Journal of experimental medicine, 183, 2669 - 2674

• Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells.

  Leach MW. et al, (1996), The American journal of pathology, 148, 1503 - 1515

• T cells in inflammatory bowel disease: protective and pathogenic roles.

  Powrie F., (1995), Immunity, 3, 171 - 174

• Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation.

  Powrie F. and Leach MW., (1995), Therapeutic immunology, 2, 115 - 123

• REGULATION OF PATHOGENIC TH1 RESPONSES AGAINST IMMUNOLOGICAL SELF-ANTIGENS BY CD45RBLOW CD4+ T-CELLS

  POWRIE F. et al, (1995), JOURNAL OF CELLULAR BIOCHEMISTRY, 152 - 152

• The role of subsets of CD4+ T cells in autoimmunity.

  Fowell D. et al, (1995), Ciba Foundation symposium, 195, 173 - 182

• Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.

  Powrie F. et al, (1994), Immunity, 1, 553 - 562

• Transfer of CD4+ T cells to C.B-17 SCID mice: a model to study Th1 and Th2 cell differentiation and regulation in vivo.

  Powrie F. et al, (1994), Research in immunology, 145, 347 - 353

• INTERLEUKIN-4 AND INTERLEUKIN-10 SYNERGIZE TO INHIBIT CELL-MEDIATED-IMMUNITY IN-VIVO (VOL 23, PG 2226, 1993)

  POWRIE F. et al, (1994), EUROPEAN JOURNAL OF IMMUNOLOGY, 24, 785 - 785

• Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

  Powrie F. et al, (1994), The Journal of experimental medicine, 179, 589 - 600

• RECIPROCAL REGULATION OF TH1 AND TH2 RESPONSES IN THE MOUSE

  COFFMAN R. and POWRIE F., (1994), CYTOKINES: BASIC PRINCIPLES AND PRACTICAL APPLICATIONS, 8, 111 - 116

• Correction: Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo (European Journal of Immunology (1993) 23 9 (2226))

  Powrie F. et al, (1994), European Journal of Immunology, 24

• CD45RBHIGH CD4+ T-CELLS INDUCE A PATHOGENIC TH1 RESPONSE IN THE COLON WHEN TRANSFERRED TO C-B-17 SCID MICE WHICH IS PREVENTED BY CO-TRANSFER OF THE CD45RBLOW POPULATION

  POWRIE F. et al, (1994), JOURNAL OF CELLULAR BIOCHEMISTRY, 418 - 418

• Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice.

  Powrie F. et al, (1993), International immunology, 5, 1461 - 1471

• Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo.

  Powrie F. et al, (1993), European journal of immunology, 23, 3043 - 3049

• Inhibition of cell-mediated immunity by IL4 and IL10.

  Powrie F. and Coffman RL., (1993), Research in immunology, 144, 639 - 643

• Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo.

  Powrie F. et al, (1993), European journal of immunology, 23, 2223 - 2229

• Cytokine regulation of T-cell function: potential for therapeutic intervention.

  Powrie F. and Coffman RL., (1993), Immunology today, 14, 270 - 274

• CYTOKINE REGULATION OF T-CELL FUNCTION - POTENTIAL FOR THERAPEUTIC INTERVENTION (REPRINTED FROM TRENDS IN PHARMACOLOGICAL SCIENCES, VOL 14, PG 164-169, 1993)

  POWRIE F. and COFFMAN R., (1993), IMMUNOLOGY TODAY, 14, 270 - 274

• Cytokine regulation of T-cell function: potential for therapeutic intervention.

  Powrie F. and Coffman RL., (1993), Trends in pharmacological sciences, 14, 164 - 168

• COOPERATION BETWEEN IL-4 AND IL-10 RESULTS IN INHIBITION OF DTH RESPONSES

  POWRIE F. et al, (1993), JOURNAL OF IMMUNOLOGY, 150, A203 - A203

• Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity.

  Fowell D. et al, (1991), Immunological reviews, 123, 37 - 64

• Lineage relationships and functions of CD4+ T-cell subsets in the rat.

  Powrie F. et al, (1991), Research in immunology, 142, 54 - 58

• CD4+ T-cell subsets: Regulation of differentiation and function: Discussion

  Swain SL. et al, (1991), Research in Immunology, 142, 68 - 79

• 35TH FORUM IN IMMUNOLOGY - DISCUSSION

  SWAIN S. et al, (1991), RESEARCH IN IMMUNOLOGY, 142, 68 - 79

• OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

  Powrie F. and Mason D., (1990), The Journal of experimental medicine, 172, 1701 - 1708

• Memory CD4+ T cells in man form two distinct subpopulations, defined by their expression of isoforms of the leucocyte common antigen, CD45.

  Mason D. and Powrie F., (1990), Immunology, 70, 427 - 433

• Subsets of rat CD4+ T cells defined by their differential expression of variants of the CD45 antigen: developmental relationships and in vitro and in vivo functions.

  Powrie F. and Mason D., (1990), Current topics in microbiology and immunology, 159, 79 - 96

• Subsets of rat CD4+ T cells express different variants of the leukocyte-common antigen: functions and developmental relationships of the subsets.

  Powrie F. and Mason D., (1989), Journal of autoimmunity, 2 Suppl, 25 - 32

• The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype.

  Powrie F. and Mason D., (1989), The Journal of experimental medicine, 169, 653 - 662

• Phenotypic and functional heterogeneity of CD4+ T cells

  Powrie F. and Mason D., (1988), Trends in Immunology, 9

• Phenotypic and functional heterogeneity of CD4+ T cells.

  Powrie F. and Mason D., (1988), Immunology today, 9, 274 - 277

• Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.

  Anderson ME. et al, (1985), Archives of biochemistry and biophysics, 239, 538 - 548

Key Publications

• The alarmin IL-33 promotes regulatory T-cell function in the intestine.

  Schiering C. et al, (2014), Nature, 513, 564 - 568

• Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.

  Kirchberger S. et al, (2013), The Journal of experimental medicine, 210, 917 - 931

• Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

  Griseri T. et al, (2012), IMMUNITY, 37, 1116 - 1129

• Intestinal homeostasis and its breakdown in inflammatory bowel disease.

  Maloy KJ. and Powrie F., (2011), Nature, 474, 298 - 306

• Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

  Buonocore S. et al, (2010), Nature, 464, 1371 - 1375

Recent Publications

• Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

  Schwerd T. et al, (2017), Gut, 66, 1060 - 1073

• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

  West NR. et al, (2017), Nature medicine, 23, 579 - 589

• Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

  Fenton TM. et al, (2017), Mucosal immunology, 10, 624 - 634

• Th1 and Innate Lymphoid Cells accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.

  Gwela A. et al, (2017), Journal of Crohn's & colitis

• Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

  Chen HH. et al, (2017), The Journal of allergy and clinical immunology, 139, 607 - 620.e15