Fiona Powrie FRS

• Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.

  Journal article

  Gwela A. et al, (2017), Journal of Crohn's & colitis, 11, 1124 - 1134

• Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

  Journal article

  Schwerd T. et al, (2017), Gut, 66, 1060 - 1073

• Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

  Journal article

  Fenton TM. et al, (2017), Mucosal Immunology, 10, 624 - 634

• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

  Journal article

  West NR. et al, (2017), Nature medicine, 23, 579 - 589

• Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

  Journal article

  Chen HH. et al, (2017), The Journal of allergy and clinical immunology, 139, 607 - 620.e15

• Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.

  Journal article

  Ilott NE. et al, (2016), The ISME Journal, 10, 2389 - 2404

• T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

  Journal article

  Krausgruber T. et al, (2016), Nature communications, 7

• Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes.

  Journal article

  Lochmatter C. et al, (2016), Scientific reports, 6

• CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.

  Journal article

  Arnold IC. et al, (2016), Mucosal Immunology, 9, 352 - 363

• CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

  Journal article

  Fergusson JR. et al, (2016), Mucosal immunology, 9, 401 - 413

• RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

  Journal article

  de Wit J. et al, (2016), The Journal of allergy and clinical immunology, 137, 960 - 963

• ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.

  Journal article

  Pearson C. et al, (2016), eLife, 5

• Immunotherapy Not Working? Check Your Microbiota.

  Journal article

  West NR. and Powrie F., (2015), Cancer cell, 28, 687 - 689

• Emerging cytokine networks in colorectal cancer.

  Journal article

  West NR. et al, (2015), Nature reviews. Immunology, 15, 615 - 629

• MICROBIOME. Microbiota RORgulates intestinal suppressor T cells.

  Journal article

  Hegazy AN. and Powrie F., (2015), Science (New York, N.Y.), 349, 929 - 930

• Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription.

  Journal article

  Alasoo K. et al, (2015), Scientific reports, 5

• Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

  Journal article

  Taylor JC. et al, (2015), Nature genetics, 47, 717 - 726

• Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.

  Journal article

  Griseri T. et al, (2015), Immunity, 43, 187 - 199

• Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis.

  Journal article

  Arnold IC. et al, (2015), Vaccine, 33, 1808 - 1814

• Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis

  Journal article

  Arnold IC. et al, (2015), Vaccine, 33, 1808 - 1814

• Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

  Journal article

  Hale C. et al, (2015), PloS one, 10

• Human ILC-T-cell interactions in inflammatory bowel disease

  Journal article

  Schaupp A-L. et al, (2014), IMMUNOLOGY, 143, 103 - 103

• A GM-CSF eosinophil axis promotes IL-23-mediated chronic intestinal inflammation

  Journal article

  Arnold IC. et al, (2014), IMMUNOLOGY, 143, 106 - 106

• The role of FoxP3(+) regulatory T-cells in psoriasiform skin disease

  Journal article

  Adelmann K. et al, (2014), IMMUNOLOGY, 143, 175 - 175

• Induced pluripotent stem cell derived macrophage is a useful cellular system to study human restricted intestinal pathogen Salmonella Typhi

  Journal article

  Hale C. et al, (2014), IMMUNOLOGY, 143, 110 - 110

• The role of FoxP3+regulatory T cells in psoriasiform skin disease

  Conference paper

  Adelmann K. et al, (2014), EXPERIMENTAL DERMATOLOGY, 23, 8 - 8

• Gut reactions: immune pathways in the intestine in health and disease

  Conference paper

  Powrie F., (2014), FEBS JOURNAL, 281, 10 - 10

• The alarmin IL-33 promotes regulatory T-cell function in the intestine.

  Journal article

  Schiering C. et al, (2014), Nature, 513, 564 - 568

• IN-VITRO SUPRESSION OF TH17 RESPONSES IN INFLAMMATORY ARTHRITIS PATIENTS USING SMALL MOLECULE ROR-GAMMA-T INHIBITORS

  Conference paper

  Al-Mossawi MH. et al, (2014), ANNALS OF THE RHEUMATIC DISEASES, 73, 357 - 357

• A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

  Journal article

  Steward-Tharp SM. et al, (2014), Blood, 123, 2978 - 2987

• Innate lymphoid cells accumulate in IBD

  Journal article

  Geremia A. et al, (2014), JOURNAL OF CROHNS & COLITIS, 8, S1 - S1

• Polyfunctionality of human gut-homing CD4 T cells

  Journal article

  Hegazy AN. et al, (2014), JOURNAL OF CROHNS & COLITIS, 8, S78 - S78

• Dendritic cell subsets in the maintenance of gut health and response to bioactives

  Journal article

  Schulthess J. et al, (2014), JOURNAL OF CROHNS & COLITIS, 8, S98 - S98

• Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease

  Journal article

  Avitzur Y. et al, (2014), Gastroenterology, 146, 1028 - 1039

• SUPPRESSION OF IN-VITRO TYPE-17 RESPONSES IN SPA PATIENTS USING SMALL MOLECULE ROR-gamma T INHIBITORS

  Journal article

  De Wit J. et al, (2014), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 32, 811 - 811

• IL-23 production by CD11c(+) mononuclear phagocytes drives chronic Helicobacter hepaticus-induced intestinal inflammation

  Conference paper

  Arnold IC. et al, (2013), IMMUNOLOGY, 140, 202 - 203

• Expression and regulation of the TGF-beta-activating integrin alpha(v)beta(8) on human dendritic cells

  Conference paper

  Fenton TM. et al, (2013), IMMUNOLOGY, 140, 147 - 148

• Controlling the frontier: regulatory T-cells and intestinal homeostasis.

  Journal article

  Bollrath J. and Powrie FM., (2013), Seminars in immunology, 25, 352 - 357

• EARLY AND NON-REVERSIBLE DECREASE OF CD161++/MUCOSAL ASSOCIATED INVARIANT T CELLS IN HIV INFECTION

  Journal article

  Cosgrove C. et al, (2013), JOURNAL OF INFECTION, 67, 342 - 343

• Immunology. Feed your Tregs more fiber.

  Journal article

  Bollrath J. and Powrie F., (2013), Science (New York, N.Y.), 341, 463 - 464

• Regulatory T cells and immune tolerance in the intestine.

  Journal article

  Harrison OJ. and Powrie FM., (2013), Cold Spring Harbor perspectives in biology, 5

• Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.

  Journal article

  Kirchberger S. et al, (2013), The Journal of experimental medicine, 210, 917 - 931

• Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.

  Journal article

  Knosp CA. et al, (2013), Journal of immunology (Baltimore, Md. : 1950), 190, 3235 - 3245

• CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.

  Journal article

  Barnes MJ. et al, (2013), Mucosal Immunology, 6, 324 - 334

• CD4(+) T-cell subsets in intestinal inflammation.

  Journal article

  Shale M. et al, (2013), Immunological reviews, 252, 164 - 182

• Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.

  Journal article

  Beverley P. et al, (2013), Vaccine, 31, 1086 - 1093

• Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.

  Journal article

  Cosgrove C. et al, (2013), Blood, 121, 951 - 961

• Innate lymphoid cells--a proposal for uniform nomenclature.

  Journal article

  Spits H. et al, (2013), Nature reviews. Immunology, 13, 145 - 149

• Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

  Journal article

  Griseri T. et al, (2012), IMMUNITY, 37, 1116 - 1129

• Gender equality: is it real?

  Journal article

  Simon K. et al, (2012), European journal of immunology, 42, 3095 - 3096

• Role of dendritics cells during IBD

  Conference paper

  Schulthess J. et al, (2012), IMMUNOLOGY, 137, 534 - 535

• The role of innate lymphoid cells in colitis-associated cancer

  Conference paper

  Kirchberger S. et al, (2012), IMMUNOLOGY, 137, 100 - 100

• Innate lymphoid cells in models of IBD

  Conference paper

  Pearson C. et al, (2012), IMMUNOLOGY, 137, 222 - 223

• Mononuclear phagocytes in steady-state and colitis

  Conference paper

  Arnold IC. et al, (2012), IMMUNOLOGY, 137, 533 - 533

• IL-1 mediates intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

  Conference paper

  Coccia M. et al, (2012), IMMUNOLOGY, 137, 532 - 532

• IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.

  Journal article

  Coccia M. et al, (2012), The Journal of experimental medicine, 209, 1595 - 1609

• Immunology: Malnutrition promotes rogue bacteria.

  Journal article

  Izcue A. and Powrie F., (2012), Nature, 487, 437 - 439

• Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

  Journal article

  Boulard O. et al, (2012), The Journal of experimental medicine, 209, 1309 - 1324

• Lymphoid microenvironments and innate lymphoid cells in the gut.

  Journal article

  Pearson C. et al, (2012), Trends in immunology, 33, 289 - 296

• Microbiota, disease, and back to health: a metastable journey.

  Journal article

  Blumberg R. and Powrie F., (2012), Science translational medicine, 4

• Gut reactions: immune pathways in the intestine in health and disease.

  Journal article

  Powrie F., (2012), EMBO molecular medicine, 4, 71 - 74

• Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8 ⁺ T cells

  Journal article

  Walker LJ. et al, (2012), Blood, 119, 422 - 433

• Re-establishing immunological self-tolerance in autoimmune disease.

  Journal article

  Sakaguchi S. et al, (2012), Nature medicine, 18, 54 - 58

• Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.

  Journal article

  Walker LJ. et al, (2012), Blood, 119, 422 - 433

• Exacerbated hematopoietic stem and progenitor cell activity during intestinal inflammation

  Conference paper

  Griseri T. and Powrie F., (2011), IMMUNOLOGY, 135, 175 - 175

• Cytokine requirements in models of inflammatory bowel disease

  Conference paper

  Pearson C. et al, (2011), IMMUNOLOGY, 135, 119 - 119

• Induction of Interleukin-10 expression by the commensal flora

  Conference paper

  Bollrath J. et al, (2011), IMMUNOLOGY, 135, 125 - 125

• SOCS2 regulates Foxp3+inducible Treg stability

  Conference paper

  Knosp CA. et al, (2011), IMMUNOLOGY, 135, 48 - 48

• Interleukin 7 signaling on DCs regulates the CD 4 T cell niche

  Conference paper

  Fewkes N. et al, (2011), IMMUNOLOGY, 135, 127 - 127

• CX(3)CR1(int) lamina propria cells accumulate during multiple models of colitis and can be distinguished from CX(3)CR1(hi) lamina propria cells by Ly6C expression

  Conference paper

  Mathisen S. et al, (2011), IMMUNOLOGY, 135, 97 - 97

• Genetic regulation of early inflammatory responses shapes a pro-carcinogenic microenvironment in a Helicobacter hepaticus-driven innate colitis model

  Conference paper

  Kirchberger S. et al, (2011), IMMUNOLOGY, 135, 105 - 105

• A hyper-IgE syndrome mouse model

  Conference paper

  Steward-Tharp S. et al, (2011), IMMUNOLOGY, 135, 174 - 174

• Gut reactions: Immune pathways in the intestine in health and disease

  Conference paper

  Powrie F., (2011), CYTOKINE, 56, 1 - 1

• Intestinal homeostasis and its breakdown in inflammatory bowel disease.

  Journal article

  Maloy KJ. and Powrie F., (2011), Nature, 474, 298 - 306

• IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease.

  Journal article

  Geremia A. et al, (2011), The Journal of experimental medicine, 208, 1127 - 1133

• Characterization of the role of IL-10 in resolution from intestinal inflammation

  Conference paper

  Szabady R. et al, (2010), IMMUNOLOGY, 131, 186 - 186

• Regulation of haematopoiesis during colitis

  Conference paper

  Griseri T. and Powrie F., (2010), IMMUNOLOGY, 131, 183 - 184

• Mouse IBD models reveal distinct pathogenic and protective roles of MyD88 signalling in epithelial cells and leukocytes

  Conference paper

  Asquith MJ. et al, (2010), IMMUNOLOGY, 131, 178 - 178

• A genetic interval confers protection from colitis and colitis-associated cancer in a model of bacteria-induced colon cancer

  Conference paper

  Kirchberger S. et al, (2010), IMMUNOLOGY, 131, 144 - 145

• Interleukin-23 drives intestinal inflammation through direct activity on T cells

  Conference paper

  Schiering C. et al, (2010), IMMUNOLOGY, 131, 56 - 56

• An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer.

  Journal article

  Asquith M. and Powrie F., (2010), The Journal of experimental medicine, 207, 1573 - 1577

• Interleukin-23 drives intestinal inflammation through direct activity on T cells.

  Journal article

  Ahern PP. et al, (2010), Immunity, 33, 279 - 288

• Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease.

  Journal article

  Asquith MJ. et al, (2010), Gastroenterology, 139, 519 - 529.e2

• Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells.

  Journal article

  Laffont S. et al, (2010), European journal of immunology, 40, 1877 - 1883

• Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

  Journal article

  Durant L. et al, (2010), Immunity, 32, 605 - 615

• E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.

  Journal article

  Siddiqui KR. et al, (2010), Immunity, 32, 557 - 567

• OX40 is required for regulatory T cell-mediated control of colitis.

  Journal article

  Griseri T. et al, (2010), The Journal of experimental medicine, 207, 699 - 709

• Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

  Journal article

  Buonocore S. et al, (2010), Nature, 464, 1371 - 1375

• TLR2-independent induction and regulation of chronic intestinal inflammation.

  Journal article

  Boulard O. et al, (2010), European journal of immunology, 40, 516 - 524

• Fiona Powrie: Gut diplomacy. Interview by Amy Maxmen.

  Journal article

  Powrie F., (2010), The Journal of experimental medicine, 207, 4 - 5

• Immunology: Dendritic-cell genealogy.

  Journal article

  Laffont S. and Powrie F., (2009), Nature, 462, 732 - 733

• Regulatory T cells reinforce intestinal homeostasis.

  Journal article

  Barnes MJ. and Powrie F., (2009), Immunity, 31, 401 - 411

• Mouse models of intestinal inflammation as tools to understand the pathogenesis of inflammatory bowel disease.

  Journal article

  Uhlig HH. and Powrie F., (2009), European journal of immunology, 39, 2021 - 2026

• Hybrid Treg cells: steel frames and plastic exteriors.

  Journal article

  Barnes MJ. and Powrie F., (2009), Nature immunology, 10, 563 - 564

• Regulatory Mechanisms in Graft-versus-Host Responses

  Journal article

  Edinger M. et al, (2009), Biology of Blood and Marrow Transplantation, 15, 2 - 6

• Regulatory mechanisms in graft-versus-host responses.

  Conference paper

  Edinger M. et al, (2009), Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 15, 2 - 6

• Regulatory lymphocytes and intestinal inflammation.

  Journal article

  Izcue A. et al, (2009), Annual review of immunology, 27, 313 - 338

• The interleukin-23 axis in intestinal inflammation.

  Journal article

  Ahern PP. et al, (2008), Immunological reviews, 226, 147 - 159

• Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis.

  Journal article

  Toms C. et al, (2008), Immunology, 125, 302 - 312

• Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.

  Journal article

  Jaensson E. et al, (2008), The Journal of experimental medicine, 205, 2139 - 2149

• Dendritic cells in intestinal immune regulation

  Journal article

  Coombes JL. and Powrie F., (2008), NATURE REVIEWS IMMUNOLOGY, 8, 435 - 446

• Dendritic cells in intestinal immune regulation.

  Journal article

  Coombes JL. and Powrie F., (2008), Nature reviews. Immunology, 8, 435 - 446

• Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis.

  Journal article

  Izcue A. et al, (2008), Immunity, 28, 559 - 570

• Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.

  Journal article

  Izcue A. and Powrie F., (2008), Immunology, 123, 6 - 10

• Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.

  Journal article

  Willoughby JE. et al, (2007), Journal of immunology (Baltimore, Md. : 1950), 179, 6836 - 6844

• Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells.

  Journal article

  Stepankova R. et al, (2007), Inflammatory bowel diseases, 13, 1202 - 1211

• The IL23 axis plays a key role in the pathogenesis of IBD.

  Journal article

  McGovern D. and Powrie F., (2007), Gut, 56, 1333 - 1336

• Emerging challenges in regulatory T cell function and biology.

  Journal article

  Sakaguchi S. and Powrie F., (2007), Science (New York, N.Y.), 317, 627 - 629

• A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.

  Journal article

  Coombes JL. et al, (2007), The Journal of experimental medicine, 204, 1757 - 1764

• Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology

  Journal article

  Uhlig HH. et al, (2007), EUROPEAN JOURNAL OF PEDIATRICS, 166, 279 - 279

• Regulatory T Cells

  Journal article

  Read S. et al, (2006), 119 - 131

• Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis.

  Journal article

  Uhlig HH. et al, (2006), Journal of immunology (Baltimore, Md. : 1950), 177, 5852 - 5860

• FOXP3+ regulatory T cells: Current controversies and future perspectives.

  Journal article

  Banham AH. et al, (2006), European journal of immunology, 36, 2832 - 2836

• Eosinophilic bowel disease controlled by the BB rat-derived lymphopenia/Gimap5 gene.

  Journal article

  Cousins L. et al, (2006), Gastroenterology, 131, 1475 - 1485

• Interleukin-23 drives innate and T cell-mediated intestinal inflammation.

  Journal article

  Hue S. et al, (2006), The Journal of experimental medicine, 203, 2473 - 2483

• IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

  Journal article

  Kullberg MC. et al, (2006), The Journal of experimental medicine, 203, 2485 - 2494

• Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.

  Journal article

  Read S. et al, (2006), Journal of immunology (Baltimore, Md. : 1950), 177, 4376 - 4383

• Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation.

  Journal article

  Izcue A. et al, (2006), Immunological reviews, 212, 256 - 271

• Untitled - Response

  Journal article

  Banham AH. and Powrie F., (2006), EUROPEAN JOURNAL OF IMMUNOLOGY, 36, 246 - 246

• Improved immune recognition through antigen targeting to the mannose receptor

  Journal article

  McKenzie EJ. et al, (2005), IMMUNOLOGY, 116, 17 - 17

• Comments on exclusion and cost [4]

  Journal article

  Powrie F., (2005), Pharmaceutical Journal, 275

• Fueling regulation: IL-2 keeps CD4+ Treg cells fit.

  Journal article

  Maloy KJ. and Powrie F., (2005), Nature immunology, 6, 1071 - 1072

• Essential role for CD103 in the T cell-mediated regulation of experimental colitis.

  Journal article

  Annacker O. et al, (2005), The Journal of experimental medicine, 202, 1051 - 1061

• The role of mucosal T lymphocytes in regulating intestinal inflammation.

  Journal article

  Uhlig HH. and Powrie F., (2005), Springer seminars in immunopathology, 27, 167 - 180

• Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level.

  Journal article

  Roncador G. et al, (2005), European journal of immunology, 35, 1681 - 1691

• Regulatory T cells and intestinal homeostasis.

  Journal article

  Coombes JL. et al, (2005), Immunological reviews, 204, 184 - 194

• A role of bacteria in inflammatory bowel disease evoked in animal models

  Journal article

  Strus M. et al, (2005), Gastroenterologia Polska, 12, 15 - 20

• T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.

  Journal article

  Fahlén L. et al, (2005), The Journal of experimental medicine, 201, 737 - 746

• Prenatal tolerance--a role for regulatory T cells?

  Journal article

  Izcue A. and Powrie F., (2005), European journal of immunology, 35, 379 - 382

• Discussion

  Journal article

  Meddings JB. et al, (2004), Novartis Foundation Symposium, 263, 145 - 150

• Final discussion

  Journal article

  Jewell DP. et al, (2004), Novartis Foundation Symposium, 263, 211 - 218

• Discussion

  Journal article

  Ghosh S. et al, (2004), Novartis Foundation Symposium, 263, 174 - 178

• Regulatory T cells.

  Journal article

  Thompson C. and Powrie F., (2004), Current opinion in pharmacology, 4, 408 - 414

• Is cod liver oil at risk? (multiple letters) [5]

  Journal article

  Powrie F. and Shotter PJ., (2004), Pharmaceutical Journal, 272

• Homing of intestinal immune cells.

  Journal article

  Uhlig HH. et al, (2004), Novartis Foundation symposium, 263, 179 - 218

• Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease.

  Journal article

  Powrie F. and Uhlig H., (2004), Novartis Foundation symposium, 263, 164 - 218

• Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses

  Journal article

  Uhlig HH. and Powrie F., (2003), JOURNAL OF CLINICAL INVESTIGATION, 112, 648 - 651

• Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses.

  Journal article

  Uhlig HH. and Powrie F., (2003), Journal of Clinical Investigation, 112, 648 - 651

• Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.

  Journal article

  Asseman C. et al, (2003), Journal of immunology (Baltimore, Md. : 1950), 171, 971 - 978

• Interleukin-10 in the regulation of T cell-induced colitis.

  Journal article

  Annacker O. et al, (2003), Journal of autoimmunity, 20, 277 - 279

• Anti-interleukin 12 antibody prevents colitis in a murine T cell transfer model of inflammatory bowel disease

  Conference paper

  Singh B. and Powrie F., (2003), BRITISH JOURNAL OF SURGERY, 90, 637 - 638

• Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells.

  Journal article

  Mottet C. et al, (2003), Journal of immunology (Baltimore, Md. : 1950), 170, 3939 - 3943

• Regulating the regulators

  Journal article

  Powrie F. and Maloy KJ., (2003), SCIENCE, 299, 1030 - 1031

• Immunology. Regulating the regulators.

  Journal article

  Powrie F. and Maloy KJ., (2003), Science (New York, N.Y.), 299, 1030 - 1031

• CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.

  Journal article

  Maloy KJ. et al, (2003), The Journal of experimental medicine, 197, 111 - 119

• Control of immune pathology by regulatory T cells.

  Journal article

  Powrie F. et al, (2003), Novartis Foundation symposium, 252, 92 - 114

• Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens.

  Journal article

  Golgher D. et al, (2002), European journal of immunology, 32, 3267 - 3275

• CTLA-4 expression on antigen-specific cells but not IL-10 secretion is required for oral tolerance.

  Journal article

  Fowler S. and Powrie F., (2002), European journal of immunology, 32, 2997 - 3006

• CD4+CD25+cells reverse established colitis in the CD4+CD45RBhigh adoptive transfer model of colitis.

  Journal article

  Mottet C. et al, (2002), CLINICAL IMMUNOLOGY, 103, S91 - S91

• Homeostasis of intestinal immune regulation.

  Journal article

  Annacker O. and Powrie F., (2002), Microbes and infection, 4, 567 - 574

• Depletion of CD25+ regulatory cells results in suppression of melanomagrowth and induction of autoreactivity in mice

  Journal article

  Jones E. et al, (2002), Cancer Immunity, 5, 1 - 12

• Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice.

  Journal article

  Jones E. et al, (2002), Cancer immunity, 2

• Immune therapy in inflammatory bowel disease and models of colitis.

  Journal article

  Singh B. et al, (2001), The British journal of surgery, 88, 1558 - 1569

• Regulatory T cells in the control of immune pathology.

  Journal article

  Maloy KJ. and Powrie F., (2001), Nature immunology, 2, 816 - 822

• Control of intestinal inflammation by regulatory T cells.

  Journal article

  Singh B. et al, (2001), Immunological reviews, 182, 190 - 200

• CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.

  Journal article

  Malmström V. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 6972 - 6981

• Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells.

  Journal article

  Read S. and Powrie F., (2001), Current protocols in immunology, Chapter 15, Unit - 15.13

• The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor.

  Journal article

  Lüttichau HR. et al, (2001), European journal of immunology, 31, 1217 - 1220

• Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro.

  Journal article

  Stephens LA. et al, (2001), European journal of immunology, 31, 1247 - 1254

• Anti-OX40Ligand treatment as a novel therapeutic strategy in a murine model of colitis

  Journal article

  Singh B. et al, (2001), GASTROENTEROLOGY, 120, A685 - A685

• IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.

  Journal article

  Hara M. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 3789 - 3796

• The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.

  Journal article

  Lucas AD. et al, (2001), The American Journal of Pathology, 158, 855 - 866

• Immature dendritic cells induce alternative CD4(+) T-cell responses in vivo.

  Conference paper

  Suri RM. et al, (2001), Transplantation proceedings, 33

• Control of experimental inflammatory bowel disease by regulatory T cells.

  Journal article

  Asseman C. et al, (2000), American journal of respiratory and critical care medicine, 162, S185 - S189

• Control of experimental inflammatory bowel disease by regulatory T cells

  Conference paper

  Asseman C. et al, (2000), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 162, S185 - +

• Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation.

  Journal article

  Read S. et al, (2000), The Journal of experimental medicine, 192, 295 - 302

• An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation.

  Journal article

  Asseman C. et al, (1999), The Journal of experimental medicine, 190, 995 - 1004

• Regulatory T cells and inflammatory bowel disease.

  Journal article

  Groux H. and Powrie F., (1999), Immunology today, 20, 442 - 445

• The role of IL-10 in inflammatory bowel disease: "of mice and men".

  Journal article

  Leach MW. et al, (1999), Toxicologic pathology, 27, 123 - 133

• Control of immune pathology by IL-10-secreting regulatory T cells.

  Journal article

  Fowler S. and Powrie F., (1999), Springer seminars in immunopathology, 21, 287 - 294

• The role of T cell subsets in hepatic inflammation in the scid model of colitis

  Journal article

  Singh B. et al, (1999), JOURNAL OF PATHOLOGY, 189, 19A - 19A

• Control of immune pathology by regulatory T cells.

  Journal article

  Mason D. and Powrie F., (1998), Current opinion in immunology, 10, 649 - 655

• CD38+ CD45RB(low) CD4+ T cells: a population of T cells with immune regulatory activities in vitro.

  Journal article

  Read S. et al, (1998), European journal of immunology, 28, 3435 - 3447

• Interleukin 10 is a growth factor for a population of regulatory T cells.

  Journal article

  Asseman C. and Powrie F., (1998), Gut, 42, 157 - 158

• Induction of CD4+ T-cell responses by dendritic cells in vivo

  Journal article

  Suri RM. et al, (1998), JOURNAL OF LEUKOCYTE BIOLOGY, 32 - 32

• CD4+ T-cells in the regulation of inflammatory responses in the intestine.

  Journal article

  Powrie F. et al, (1997), Research in immunology, 148, 576 - 581

• Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus.

  Journal article

  Cahill RJ. et al, (1997), Infection and immunity, 65, 3126 - 3131

• A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

  Journal article

  Powrie F. et al, (1996), The Journal of experimental medicine, 183, 2669 - 2674

• Inflammatory bowel disease in C.B-17 scid mice reconstituted with the CD45RBhigh subset of CD4+ T cells.

  Journal article

  Leach MW. et al, (1996), The American journal of pathology, 148, 1503 - 1515

• T cells in inflammatory bowel disease: protective and pathogenic roles.

  Journal article

  Powrie F., (1995), Immunity, 3, 171 - 174

• Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation.

  Journal article

  Powrie F. and Leach MW., (1995), Therapeutic immunology, 2, 115 - 123

• REGULATION OF PATHOGENIC TH1 RESPONSES AGAINST IMMUNOLOGICAL SELF-ANTIGENS BY CD45RBLOW CD4+ T-CELLS

  Journal article

  POWRIE F. et al, (1995), JOURNAL OF CELLULAR BIOCHEMISTRY, 152 - 152

• The role of subsets of CD4+ T cells in autoimmunity.

  Conference paper

  Fowell D. et al, (1995), Ciba Foundation symposium, 195, 173 - 182

• Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.

  Journal article

  Powrie F. et al, (1994), Immunity, 1, 553 - 562

• Transfer of CD4+ T cells to C.B-17 SCID mice: a model to study Th1 and Th2 cell differentiation and regulation in vivo.

  Journal article

  Powrie F. et al, (1994), Research in immunology, 145, 347 - 353

• INTERLEUKIN-4 AND INTERLEUKIN-10 SYNERGIZE TO INHIBIT CELL-MEDIATED-IMMUNITY IN-VIVO (VOL 23, PG 2226, 1993)

  Journal article

  POWRIE F. et al, (1994), EUROPEAN JOURNAL OF IMMUNOLOGY, 24, 785 - 785

• Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

  Journal article

  Powrie F. et al, (1994), The Journal of experimental medicine, 179, 589 - 600

• Correction: Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo (European Journal of Immunology (1993) 23 9 (2226))

  Journal article

  Powrie F. et al, (1994), European Journal of Immunology, 24

• RECIPROCAL REGULATION OF TH1 AND TH2 RESPONSES IN THE MOUSE

  Conference paper

  COFFMAN R. and POWRIE F., (1994), CYTOKINES: BASIC PRINCIPLES AND PRACTICAL APPLICATIONS, 8, 111 - 116

• CD45RBHIGH CD4+ T-CELLS INDUCE A PATHOGENIC TH1 RESPONSE IN THE COLON WHEN TRANSFERRED TO C-B-17 SCID MICE WHICH IS PREVENTED BY CO-TRANSFER OF THE CD45RBLOW POPULATION

  Journal article

  POWRIE F. et al, (1994), JOURNAL OF CELLULAR BIOCHEMISTRY, 418 - 418

• Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo.

  Journal article

  Powrie F. et al, (1993), European journal of immunology, 23, 3043 - 3049

• Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice.

  Journal article

  Powrie F. et al, (1993), International immunology, 5, 1461 - 1471

• Inhibition of cell-mediated immunity by IL4 and IL10.

  Journal article

  Powrie F. and Coffman RL., (1993), Research in immunology, 144, 639 - 643

• Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo.

  Journal article

  Powrie F. et al, (1993), European journal of immunology, 23, 2223 - 2229

• CYTOKINE REGULATION OF T-CELL FUNCTION - POTENTIAL FOR THERAPEUTIC INTERVENTION (REPRINTED FROM TRENDS IN PHARMACOLOGICAL SCIENCES, VOL 14, PG 164-169, 1993)

  Journal article

  POWRIE F. and COFFMAN R., (1993), IMMUNOLOGY TODAY, 14, 270 - 274

• Cytokine regulation of T-cell function: potential for therapeutic intervention.

  Journal article

  Powrie F. and Coffman RL., (1993), Immunology today, 14, 270 - 274

• Cytokine regulation of T-cell function: potential for therapeutic intervention.

  Journal article

  Powrie F. and Coffman RL., (1993), Trends in pharmacological sciences, 14, 164 - 168

• COOPERATION BETWEEN IL-4 AND IL-10 RESULTS IN INHIBITION OF DTH RESPONSES

  Journal article

  POWRIE F. et al, (1993), JOURNAL OF IMMUNOLOGY, 150, A203 - A203

• Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity.

  Journal article

  Fowell D. et al, (1991), Immunological reviews, 123, 37 - 64

• CD4+ T-cell subsets: Regulation of differentiation and function: Discussion

  Journal article

  Swain SL. et al, (1991), Research in Immunology, 142, 68 - 79

• 35TH FORUM IN IMMUNOLOGY - DISCUSSION

  Journal article

  SWAIN S. et al, (1991), RESEARCH IN IMMUNOLOGY, 142, 68 - 79

• Lineage relationships and functions of CD4+ T-cell subsets in the rat.

  Journal article

  Powrie F. et al, (1991), Research in immunology, 142, 54 - 58

• OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

  Journal article

  Powrie F. and Mason D., (1990), The Journal of experimental medicine, 172, 1701 - 1708

• Memory CD4+ T cells in man form two distinct subpopulations, defined by their expression of isoforms of the leucocyte common antigen, CD45.

  Journal article

  Mason D. and Powrie F., (1990), Immunology, 70, 427 - 433

• Subsets of rat CD4+ T cells defined by their differential expression of variants of the CD45 antigen: developmental relationships and in vitro and in vivo functions.

  Journal article

  Powrie F. and Mason D., (1990), Current topics in microbiology and immunology, 159, 79 - 96

• Subsets of rat CD4+ T cells express different variants of the leukocyte-common antigen: functions and developmental relationships of the subsets.

  Journal article

  Powrie F. and Mason D., (1989), Journal of autoimmunity, 2 Suppl, 25 - 32

• The MRC OX-22- CD4+ T cells that help B cells in secondary immune responses derive from naive precursors with the MRC OX-22+ CD4+ phenotype.

  Journal article

  Powrie F. and Mason D., (1989), The Journal of experimental medicine, 169, 653 - 662

• Phenotypic and functional heterogeneity of CD4+ T cells

  Journal article

  Powrie F. and Mason D., (1988), Trends in Immunology, 9

• Phenotypic and functional heterogeneity of CD4+ T cells.

  Journal article

  Powrie F. and Mason D., (1988), Immunology today, 9, 274 - 277

• Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.

  Journal article

  Anderson ME. et al, (1985), Archives of biochemistry and biophysics, 239, 538 - 548

Key Publications

• The alarmin IL-33 promotes regulatory T-cell function in the intestine.

  Journal article

  Schiering C. et al, (2014), Nature, 513, 564 - 568

• Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.

  Journal article

  Kirchberger S. et al, (2013), The Journal of experimental medicine, 210, 917 - 931

• Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

  Journal article

  Griseri T. et al, (2012), IMMUNITY, 37, 1116 - 1129

• Intestinal homeostasis and its breakdown in inflammatory bowel disease.

  Journal article

  Maloy KJ. and Powrie F., (2011), Nature, 474, 298 - 306

• Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

  Journal article

  Buonocore S. et al, (2010), Nature, 464, 1371 - 1375

Recent Publications

• Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.

  Journal article

  Gwela A. et al, (2017), Journal of Crohn's & colitis, 11, 1124 - 1134

• Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

  Journal article

  Schwerd T. et al, (2017), Gut, 66, 1060 - 1073

• Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

  Journal article

  Fenton TM. et al, (2017), Mucosal Immunology, 10, 624 - 634

• Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

  Journal article

  West NR. et al, (2017), Nature medicine, 23, 579 - 589

• Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

  Journal article

  Chen HH. et al, (2017), The Journal of allergy and clinical immunology, 139, 607 - 620.e15