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By changing mouse genes to block a protein associated with obesity, researchers at the Kennedy Institute of Rheumatology, NDORMS have prevented fat from forming around the animals' internal organs, even when the animals eat an unhealthy diet. The study in Nature Medicine found that these genetically engineered mice also retained their sensitivity to insulin (normally blunted by obesity), despite gaining weight.
NHS baby check may miss dislocated hips in new-born babies
Botnar Hip Main
25 April 2024
A new study has identified that NHS infant checks can miss serious hip abnormalities in new-born babies. Left undetected, these can require complex surgery, and lead to early arthritis. In the UK around 500 infants undergo surgery for dislocated hips which could have been avoidable.
New Study uses AI to predict malaria outbreaks in South Asia
Botnar Main
23 April 2024
Researchers from NDORMS in collaboration with international institutions have demonstrated the potential of using environmental measurements and deep learning modeling to predict malaria outbreaks in South Asia. The study offers promising insights into improving early warning systems for one of the world's deadliest diseases.
New TRIPOD+AI guidelines reflect growing use of AI in healthcare research
Botnar CSM Main
16 April 2024
The widespread use of artificial intelligence (AI) in medical decision-making tools has led to an update of the TRIPOD guidelines for reporting clinical prediction models. The new TRIPOD+AI guidelines are launched in the BMJ today.
COVID-19 vaccines effectiveness: results from Norway demonstrate the reproducibility of federated analytics
Botnar Coronavirus COVID-19 Main Statistics and epidemiology
11 April 2024
Researchers from NDORMS and the University of Oslo, have successfully replicated findings from recently published international studies on the effectiveness of COVID-19 vaccines to prevent long COVID and post-acute complications.
Simon Matthew Graham awarded an MRC Clinician Scientist Fellowship
Botnar Funding Main Orthopaedics and trauma
26 March 2024
The award from the Medical Research Council (MRC) will support research to improve treatments for open fractures in low- and middle-income countries.
New framework guides the use of AI for clinical diagnosis
Botnar Main Research
25 March 2024
NDORMS researchers have conducted a review of the literature on the use of AI in clinical decision-making. Published in the Lancet the study identifies why AI has not yet been taken up more widely, and provides a framework to better inform future adoption and integration of the technology.
New study reveals long-term mental health risks after COVID-19
Botnar Coronavirus COVID-19 Main Statistics and epidemiology
21 March 2024
A new study published in Nature Human Behaviour sheds light on the long-term mental health consequences of COVID-19 infection and the growing evidence of the protective effect of vaccination on reducing the risk.
AI Software yields six-fold increase in spine fracture identification
Botnar Main
19 March 2024
Early findings in the ADOPT study, show that Nanox.AI software improves the detection of spine fractures, an early sign of osteoporosis, outperforming UK National Health Service national average.
Professor Gary Collins awarded prestigious NIHR Senior Investigator award
Awards Botnar CSM Department General Main
15 March 2024
NDORMS Professor of Medical Statistics and Director of the Centre for Statistics in Medicine, Gary Collins has been appointed National Institute of Health Research (NIHR) Senior Investigator.
New bronchoscopy capability expands capacity for respiratory and vaccine trials
Botnar Main Trials
14 March 2024
The NIHR Oxford Clinical Research Facility (EMCRF) hosted by NDORMS has expanded its capability to undertake research bronchoscopies. The facility welcomed its first volunteers as part of the Oxford Airways Study to help understand the causes of asthma.
COVID jab linked to lower risk of COVID-19-related clot and heart complications
Botnar Main Statistics and epidemiology
13 March 2024
NDORMS research shows that vaccination reduced the risk of heart failure and some clot-related complications for up to a year.
Removing bias from healthcare AI tools
Botnar Main Research Statistics and epidemiology
22 February 2024
Rapid advances in Artificial Intelligence (AI) have opened the way for the creation of a huge range of new healthcare tools, but to ensure that these tools do not exacerbate preexisting health inequities, researchers urge the use of more representative data in their development.
New research improves accuracy of molecular quantification in high throughput sequencing
Botnar Main Research
5 February 2024
A team at NDORMS has developed a new approach to significantly improve the accuracy of RNA sequencing. They pinpoint the primary source of inaccurate quantification in both short and long-read RNA sequencing, and have introduced the concept of “majority vote” error correction leading to a substantial improvement in RNA molecular counting.
New reporting guideline will provide transparency in consensus research
Botnar CSM Main
24 January 2024
Published in PLOS, the new guideline will help the scientific community to write complete and transparent research reports involving consensus methods.
NDORMS hosts a visit from Taipei Medical University researchers
Botnar Main
18 January 2024
NDORMS welcomed a delegation of medical researchers from Taipei Medical University this week to exchange research ideas and for potential future collaborations.
COVID-19 vaccines found effective in reducing long COVID symptoms
Botnar Coronavirus COVID-19 Main Statistics and epidemiology
12 January 2024
A recent study has revealed the effectiveness of COVID-19 vaccines in preventing long COVID.
Study reveals inequalities in access to shoulder replacement surgery
Botnar Main Shoulder
27 October 2023
As demand for shoulder replacement surgery grows, a new study finds that up to 1 in 6 patients are having to travel to a different region for surgery, and exposes a year on year increase in the risk of serious adverse events after surgery that require admission to hospital.
First UK spine fracture patients identified by NHS-X and Nanox.AI Artificial Intelligence research study
Botnar Main
20 October 2023
The NHS ADOPT study has now begun to automatically identify patients with vertebral fracture, by using Nanox.AI an Artificial Intelligence (AI) programme to review thousands of hospital computed tomography (CT) scans. The patients are now being fast-tracked for bone health assessment by an NHS osteoporosis team.
Daniele Cotton wins St Edmund Hall’s Ex Aula Prize
Awards Botnar Main
18 October 2023
Congratulations to Daniele Cotton winner of St Edmund Hall’s graduate research journal prize for his article ‘Jailbreak – Preventing Metastatic Cancer.’
Psoriatic arthritis awareness day - a patients story
Botnar Main Trials
28 September 2023
The early warning signs of psoriatic arthritis (PsA) can be hard to spot. Any delay in diagnosis of PsA can leave patients uncomfortable and in pain. But slow diagnosis is all too common, according to Professor Laura Coates. She is leading a new study called HPOS, that is looking for 2000 UK volunteers to chart their psoriasis symptoms, and which may help to explain why one third of psoriasis patients to go on to develop arthritis.