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Aspirin could be used as an anti-inflammatory drug, bringing relief to the thousands who suffer with shoulder pain, researchers at NDORMS have found.
TCRs drive CARs
1 May 2025
Researchers have developed an innovative dual-receptor T-cell therapy that promises safer and more effective cancer treatments. This study, published in Cell, demonstrates that engineering T-cells to express both a Chimeric Antigen Receptor (CAR) and a T-cell Receptor (TCR) can improve their ability to distinguish between cancerous and healthy tissues—addressing a major challenge in current immunotherapy.
Common virus may improve skin cancer treatment outcomes, study finds
25 April 2025
A new study led by the University of Oxford has revealed that a common and usually harmless virus may positively influence how skin cancer patients respond to current treatments.
New research uncovers pathways to prevent premature cell death
28 March 2025
New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKe, play a crucial role in preventing premature cell death, which can lead to serious inflammation in the body. The findings are particularly relevant for people with a mutation in the TBK1 gene who often develop multiorgan inflammation caused by excessive cell death even in the absence of any infection.
Decoding the interplay between genes and mechanics in tissues at single-cell resolution
17 March 2025
Researchers at the Kennedy Institute have developed a new computational framework that allows simultaneous analysis of gene expression and mechanical forces within cells and tissues, uncovering insights into how the interplay between transcriptional and mechanical signals guides processes such as cell fate decisions or the formation of spatially distinct tissue compartments.
Pancreatic cancer immune map provides clues for precision treatment targeting
7 February 2025
Study shows why there are differences in prognosis between different pancreatic tumours and identifies potential avenues for improved treatment approaches.
An interview with Audrey Gerard
21 January 2025
Audrey Gerard, an Associate Professor of Immune Cell Dynamics and Principal Investigator at the Kennedy Institute of Rheumatology, is working to understand how the immune response interacts with and shapes tumours.
Professor Michael Dustin named AAI Distinguished Fellow
20 January 2025
The American Association of Immunologists (AAI) has recognised the outstanding work of the Kennedy Institute’s Professor of Molecular Immunology Michael Dustin by naming him a Distinguished Fellow of AAI.
How an 'optional' amino acid is required for an optimal immune response
3 January 2025
A new study conducted by researchers at the Kennedy Institute of Rheumatology has uncovered a pivotal role of asparagine metabolism in regulating B cell homeostasis and immune response.
Paul Kubes joins the Kennedy Institute as the Newton-Abraham Visiting Professor
9 December 2024
Paul joined the Kennedy Institute in September 2024 as part of the Newton-Abraham Visiting Professorship, a prestigious award given by the University of Oxford to the most distinguished scholars in the biological, chemical or medical sciences.
Dr Kate Coldwell awarded Daphne Jackson Fellowship to study links between liver disease and gut bacteria
17 September 2024
Dr Kate Coldwell has joined the Oxford Centre for Microbiome Studies at the Kennedy Institute to study the links between liver disease and gut bacteria, having been awarded the Daphne Jackson Fellowship, co-funded by the Kennedy Trust for Rheumatology Research (KTRR) and the Medical Research Council.
Kennedy scientists honoured with Royal Society Medal
16 September 2024
Professor Sir Ravinder Maini and Professor Sir Marc Feldmann have jointly received The Royal Society’s Royal Medal (Applied) for inventing anti-TNF therapy to treat rheumatoid arthritis (RA), bringing it from bench to bedside in one of the biggest success stories of modern medicine.
CRUK funding will help develop new targets for ovarian cancer
21 August 2024
Irina Udalova has received funding from Cancer Research UK (CRUK) to study the diverse role of neutrophils in ovarian cancer.
The Kennedy Institute welcomes Distinguished Investigator Dr Alan Sher
4 June 2024
Alan has spent two months at the Kennedy Institute as a guest of Professor Dame Fiona Powrie. During his visit he has spent his time collaborating with researchers at the Kennedy and other departments in the University, and mentoring young investigators on their career development.
Oxford researchers contribute to report on the future of healthcare
23 May 2024
Prof. Michael Dustin was one of 17 researchers from across Oxford's Medical Sciences and Maths, Physics and Life Sciences Divisions that have contributed to a new report on the future of healthcare, compiled by Citi Global Perspectives & Solutions (Citi GPS).
NDORMS researchers awarded Associate Professor title
9 May 2024
The University of Oxford has awarded the title of Associate Professor to Calliope Dendrou and Siim Pauklin.
Connects-UK launches to foster scientific collaborations between EU and UK researchers in a post-Brexit era
10 April 2024
Connects-UK, a new pan-European network dedicated to advancing scientific collaborations between researchers in the European Union (EU) and the United Kingdom (UK), was officially launched at an event in London yesterday. The network, led by a diaspora of EU researchers working in the UK, seeks to bridge the gap created by Brexit and ensure that collaboration, innovative research, funding, and knowledge exchange continue to thrive in the post-Brexit era.
New study reveals how T cells gain and maintain tolerance to gut bacteria
4 April 2024
The immune system in the intestine maintains a careful balance, tolerating our long-term resident (commensal) gut bacteria while defending against invading pathogens. Under certain circumstances, dysregulation of our intestinal immune response to commensal and pathogenic microbes can drive inflammatory disease.
PD-1 gets an “A” for team-work
8 March 2024
A new understanding of the PD-1 axis (programmed death cell) could help shape ongoing efforts to improve treatments for cancer and autoimmune diseases.
Professor Irina Udalova appointed to the MRC’s Infections and Immunity Board
1 March 2024
The Medical Research Council’s Infections and Immunity Board (IIB) funds research into infectious human disease and disorders of the human immune system.
Oxford-ZEISS Centre of Excellence officially opened
23 February 2024
ZEISS is partnering with the University of Oxford bringing ground-breaking microscopy imaging equipment, and analysis tools, to advance the study of global health and disease.