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New research at the Kennedy Institute reveals potential of a novel class of drugs for the treatment of rheumatoid arthritis.

cIAP inhibitors restore a healthy balance between inflammatory and regulatory T lymphocytes to reduce inflammatory arthritis

TCRs drive CARs

Researchers have developed an innovative dual-receptor T-cell therapy that promises safer and more effective cancer treatments. This study, published in Cell, demonstrates that engineering T-cells to express both a Chimeric Antigen Receptor (CAR) and a T-cell Receptor (TCR) can improve their ability to distinguish between cancerous and healthy tissues—addressing a major challenge in current immunotherapy.

Multilingual animations launched

Common virus may improve skin cancer treatment outcomes, study finds

A new study led by the University of Oxford has revealed that a common and usually harmless virus may positively influence how skin cancer patients respond to current treatments.

CRUK funding for research into earlier detection of relapse in people with multiple myeloma

Dr Karthik Ramasamy and team will assess a new mass spectrometry-based monitoring technique for its ability to predict and identify early disease relapse.

New ultrasound drug delivery system found to be highly effective against bacterial biofilms

Researchers at the University of Oxford have developed a new drug delivery system using ultrasound-activated nanoparticles to break through and destroy bacterial biofilms. This offers a promising solution that could address the global crisis of chronic antibiotic-resistant infections affecting hundreds of millions of people worldwide.

New research highlights colorectal cancer trends and survival rates

A recent study published in the American Journal of Gastroenterology investigates the incidence and survival rates of colorectal cancer (CRC) in the UK. The research offers healthcare decision-makers crucial insights for planning, management and screening for colorectal cancer.

New CONSORT reporting guidelines published today in five medical journals

The CONSORT 2025 statement, an updated guideline for reporting randomised trials is being simultaneously published in The BMJ, JAMA, The Lancet, Nature Medicine, and PLOS Medicine.

NDORMS leads study on burosumab for adults with rare inherited disorder

NDORMS researchers have been awarded funding to explore the long-term effects of burosumab in adults with X-linked hypophosphataemia (XLH).

Blood cancer patients should continue treatment at time of COVID-19 vaccination, OCTRU study shows

Evidence shows for patients with a type of leukaemia, pausing BTKi therapy for COVID-19 vaccination does not improve antibody responses to the vaccine

Global study supports the immunity debt hypothesis for flu after Covid restrictions

A new NDORMS study supports the hypothesis of immunity debt showing increases of influenza rates one year after global relaxation of COVID-19 restrictions. It highlights the need for proactive preparations in future pandemic response strategies.

PROBAST+AI guidelines updated to improve AI quality assessment

The PROBAST+AI guidelines have been updated to provide clearer, more comprehensive standards for evaluating artificial intelligence (AI) models in healthcare research. Originally introduced to assess the risk of bias and the robustness of prediction models, they have been revised to address the growing importance of AI in healthcare decision-making.

IMPROVE Trial Results Reported

TRANSLATE Study Main Results Published

Results paper published from the TRANSLATE study

New research uncovers pathways to prevent premature cell death

New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKe, play a crucial role in preventing premature cell death, which can lead to serious inflammation in the body. The findings are particularly relevant for people with a mutation in the TBK1 gene who often develop multiorgan inflammation caused by excessive cell death even in the absence of any infection.

SCT's 2025 Class of Fellows announced

The Society for Clinical Trials (SCT) is an educational, charitable, and scientific organization whose mission is to work internationally to advance human health through advocating the use of clinical trials, leading the development and dissemination of optimal methods and practices in clinical trials, and educating and developing all clinical trial professionals. This week the SCT 2025 Class of Fellows was announced and one of OCTRUs current interim directors - Professor Jonathan Cook was listed in that Class - A great accolade. Jonathan will be presented with his award during the SCT 2025 Annual Meeting in Vancouver in May.

TaILOR Study Opens to Recruitment!

Decoding the interplay between genes and mechanics in tissues at single-cell resolution

Researchers at the Kennedy Institute have developed a new computational framework that allows simultaneous analysis of gene expression and mechanical forces within cells and tissues, uncovering insights into how the interplay between transcriptional and mechanical signals guides processes such as cell fate decisions or the formation of spatially distinct tissue compartments.

Innovative bead design will enhance single-cell transcriptomics accuracy

Researchers at NDORMS have made an important advancement in the field of single-cell transcriptomics by developing a novel bead design that reduces errors in DNA synthesis and improves the reliability of gene expression measurements.

New guidelines to build trusted AI in healthcare research

A new set of guidelines have been launched to create trustworthy AI systems in healthcare. The first of its kind, the FUTURE-AI guideline provides recommendations covering the entire lifecycle of medical AI, from design, development and validation to regulation, deployment, and monitoring.

NDORMS receives funding to tackle the global burden of musculoskeletal injuries

A grant from the National Institute for Health and Care Research (NIHR) is funding a study to improve healthcare treatment and care for patients with broken bones in three Sub-Saharan Africa countries.

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cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs

Scientific Advances 2019

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Two targets are better than one 

Nature Reviews Rheumatology

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Anti-TNF Drugs

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