Richard Williams

• Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis.

  Hull DN. et al, (2016), Arthritis research & therapy, 18

• Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis

  Hull DN. et al, (2016), ARTHRITIS RESEARCH & THERAPY, 18

• TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases.

  Bystrom J. et al, (2016), Cytokine

• Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

  Kawalkowska J. et al, (2016), Scientific reports, 6

• Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis.

  Kawalkowska JZ. et al, (2016), European journal of immunology, 46, 1246 - 1257

• Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.

  Ghari F. et al, (2016), Science advances, 2

• Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade.

  Kaneko K. et al, (2016), Arthritis & rheumatology (Hoboken, N.J.), 68, 521 - 531

• Role of the Kynurenine Pathway in Immune-Mediated Inflammation

  Cribbs AP. and Williams RO., (2015), Targeting the Broadly Pathogenic Kynurenine Pathway

• Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

  Cole JE. et al, (2015), Proceedings of the National Academy of Sciences of the United States of America, 112, 13033 - 13038

• TNF-Alpha Receptor II Signaling Plays an Important Role in Maintaining the Expression of Forkhead Box P3 in Murine Regulatory T Cells

  Tseng W-Y. et al, (2015), ARTHRITIS & RHEUMATOLOGY, 67

• Immunomodulation By a Second-Generation Peptidyl Arginine Deiminase Inhibitor Abrogates Collagen-Induced Arthritis in a Therapeutic Protocol

  Quirke A-M. et al, (2015), ARTHRITIS & RHEUMATOLOGY, 67

• CGEN-15001, a Novel B7-like Protein, Controls Inflammation in a Translational Rheumatoid Arthritis (RA) Assay and Induces Treg Driven Long-Term Remission in an Autoimmune Disease Model

  Hecht I. et al, (2015), ARTHRITIS & RHEUMATOLOGY, 67

• Anti-tumour necrosis factor treatment increases circulating T helper type 17 cells similarly in different types of inflammatory arthritis.

  Hull DN. et al, (2015), Clinical and experimental immunology, 181, 401 - 406

• Anti-tumour necrosis factor treatment increases circulating T helper type 17 cells similarly in different types of inflammatory arthritis

  Hull DN. et al, (2015), Clinical and Experimental Immunology, 181, 401 - 406

• Applying refinement to the use of mice and rats in rheumatoid arthritis research.

  Hawkins P. et al, (2015), Inflammopharmacology, 23, 131 - 150

• IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.

  Blazek K. et al, (2015), The Journal of experimental medicine, 212, 845 - 853

• Reply: To PMID 24891289.

  Cribbs AP. and Williams RO., (2015), Arthritis & rheumatology (Hoboken, N.J.), 67, 1406 - 1407

• Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis.

  Cribbs AP. et al, (2015), Arthritis & rheumatology (Hoboken, N.J.), 67, 1182 - 1192

• Harnessing the Therapeutic Potential of Th17 Cells.

  Bystrom J. et al, (2015), Mediators of inflammation, 2015

• Combination cytokine blockade: the way forward in therapy for rheumatoid arthritis?

  Taylor PC. and Williams RO., (2015), Arthritis & rheumatology (Hoboken, N.J.), 67, 14 - 16

• Chapter 7: Role of the kynurenine pathway in immune- mediated infl ammation

  Cribbs AP. and Williams RO., (2015), Targeting the Broadly Pathogenic Kynurenine Pathway, 93 - 107

• Regulatory T-cell suppression is restored following methotrexate-mediated demethylation of the Foxp3 upstream enhancer in patients with rheumatoid arthritis

  Cribbs AP. et al, (2014), IMMUNOLOGY, 143, 153 - 153

• Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

  McCann FE. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 2728 - 2738

• CGEN-15001, a Novel Immunomodulatory Fusion Protein of the B7 Family Induces Immune Tolerance and Shows Efficacy in Mouse Models of Rheumatoid Arthritis and Psoriasis.

  Hecht I. et al, (2014), ARTHRITIS & RHEUMATOLOGY, 66, S1027 - S1028

• Treg Cell Function in Rheumatoid Arthritis Is Compromised by CTLA-4 Promoter Methylation Resulting in a Failure to Activate the Indoleamine 2,3-Dioxygenase Pathway

  Cribbs AP. et al, (2014), ARTHRITIS & RHEUMATOLOGY, 66, 2344 - 2354

• Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.

  Cribbs AP. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 2344 - 2354

• INCREASE IN CIRCULATING TH17 CELLS DURING ANTI-TNF THERAPY IN RHEUMATOID ARTHRITIS PATIENTS IS ASSOCIATED WITH IMPROVEMENT IN JOINT INFLAMMATION

  Hull D. et al, (2014), ANNALS OF THE RHEUMATIC DISEASES, 73, 236 - 236

• TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

  Ruspi G. et al, (2014), Cellular signalling, 26, 683 - 690

• ANTI-TNF THERAPY LEADS TO AN INCREASE IN CIRCULATING TH17 CELLS IN PATIENTS WITH DIFFERENT TYPES OF INFLAMMATORY ARTHRITIS AND IS ASSOCIATED WITH ULTRASONOGRAPHIC IMPROVEMENT OF SYNOVITIS

  Hull DN. et al, (2014), RHEUMATOLOGY, 53, 42 - 43

• Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis.

  Al-Abd AM. et al, (2014), PloS one, 9

• Blockade of tumour necrosis factor-α in experimental autoimmune encephalomyelitis reveals differential effects on the antigen-specific immune response and central nervous system histopathology.

  Batoulis H. et al, (2014), Clinical and experimental immunology, 175, 41 - 48

• Heat shock protein B1-deficient mice display impaired wound healing.

  Crowe J. et al, (2013), PloS one, 8

• Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis.

  Williams RO., (2013), International journal of tryptophan research : IJTR, 6, 67 - 73

• Mapping pathogenesis of arthritis through small animal models.

  Vincent TL. et al, (2012), Rheumatology (Oxford, England), 51, 1931 - 1941

• Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.

  Alzabin S. et al, (2012), Annals of the rheumatic diseases, 71, 1741 - 1748

• CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation.

  Hernangómez M. et al, (2012), Glia, 60, 1437 - 1450

• CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation

  Hernangómez M. et al, (2012), GLIA, 60, 1437 - 1450

• Effector T cells in rheumatoid arthritis: lessons from animal models.

  Alzabin S. and Williams RO., (2011), FEBS letters, 585, 3649 - 3659

• Kynurenine metabolism in health and disease.

  Kolodziej LR. et al, (2011), Amino acids, 41, 1173 - 1183

• IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

  McNamee KE. et al, (2011), Pain, 152, 1838 - 1845

• ANTI TNF THERAPY IN RHEUMATOID ARTHRITIS

  Feldmann M. et al, (2011), INFLAMMATION RESEARCH, 60, 31 - 31

• TNF-INDUCIBLE INHIBITOR I-KAPPAB EPSILON MODULATES IL-2 EXPRESSION IN T CELLS THROUGH REGULATION OF C-REL: IMPLICATIONS FOR CHRONIC INFLAMMATORY DISEASE

  Clark JM. et al, (2011), ADVANCES IN TNF FAMILY RESEARCH, 691, 710 - 711

• Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells.

  Clark JM. et al, (2011), PloS one, 6

• Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis.

  Al-Abd AM. et al, (2010), European journal of pharmacology, 644, 245 - 250

• The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity.

  Weng L. et al, (2010), Annals of the rheumatic diseases, 69, 1519 - 1526

• SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

  Drexler SK. et al, (2010), Arthritis and rheumatism, 62, 2249 - 2261

• Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain.

  McNamee KE. et al, (2010), Pain, 149, 386 - 392

• Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors.

  Sacre S. et al, (2010), Arthritis and rheumatism, 62, 683 - 693

• What have we learnt from targeted anti-TNF therapy?

  Feldmann M. et al, (2010), Annals of the rheumatic diseases, 69 Suppl 1, i97 - i99

• Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis.

  McCann FE. et al, (2010), Arthritis research & therapy, 12

• ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis.

  Notley CA. et al, (2010), Arthritis and rheumatism, 62, 171 - 178

• Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis.

  Criado G. et al, (2009), Arthritis and rheumatism, 60, 1342 - 1351

• Amphoteric liposomes enable systemic antigen-presenting cell-directed delivery of CD40 antisense and are therapeutically effective in experimental arthritis.

  Andreakos E. et al, (2009), Arthritis and rheumatism, 60, 994 - 1005

• Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.

  Notley CA. et al, (2008), The Journal of experimental medicine, 205, 2491 - 2497

• Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.

  Inglis JJ. et al, (2008), Arthritis and rheumatism, 58, 3110 - 3119

• Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

  Raichel L. et al, (2008), European journal of immunology, 38, 2905 - 2915

• Plasmid DNA as a safe gene delivery vehicle for treatment of chronic inflammatory disease.

  Clanchy FI. and Williams RO., (2008), Expert opinion on biological therapy, 8, 1507 - 1519

• Novel Approaches to the Therapy of Rheumatoid Arthritis based on an Understanding of Disease Mechanisms

  McCann F. and Williams R., (2008), Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 8, 275 - 284

• CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.

  Simelyte E. et al, (2008), Arthritis and rheumatism, 58, 1038 - 1043

• Protocol for the induction of arthritis in C57BL/6 mice.

  Inglis JJ. et al, (2008), Nature protocols, 3, 612 - 618

• Paradoxical effects of tumour necrosis factor-alpha in adjuvant-induced arthritis.

  Williams RO., (2008), Arthritis research & therapy, 10

• Prolonged response to anti-tumour necrosis factor treatment with adalimumab (Humira) in relapsing polychondritis complicated by aortitis.

  Seymour MW. et al, (2007), Rheumatology (Oxford, England), 46, 1738 - 1739

• The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.

  Inglis JJ. et al, (2007), Rheumatology (Oxford, England), 46, 1428 - 1432

• Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.

  Williams RO. et al, (2007), Current opinion in pharmacology, 7, 412 - 417

• Anti-CD3 antibody-induced suppression of collagen-induced arthritis in the DBA/1 mouse is associated with expansion of regulatory T cell subsets

  Notley CA. et al, (2007), IMMUNOLOGY, 120, 7 - 8

• Collagen-induced arthritis in mice.

  Williams RO., (2007), Methods in molecular medicine, 136, 191 - 199

• Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha.

  Williams RO., (2007), Methods in molecular biology (Clifton, N.J.), 361, 265 - 284

• Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint.

  Marinova-Mutafchieva L. et al, (2006), Clinical and experimental immunology, 146, 287 - 293

• Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.

  Andreakos E. et al, (2006), Proceedings of the National Academy of Sciences of the United States of America, 103, 14459 - 14464

• Systemic delivery of an antisense oligonucleotide and treatment of established collagen-induced arthritis by a novel charge-reversible liposomal formulation

  Andreakos E. et al, (2006), ANNALS OF THE RHEUMATIC DISEASES, 65, A45 - A45

• Pathogenesis and therapy of rheumatoid arthritis.

  Williams RO., (2006), Ernst Schering Foundation symposium proceedings, 107 - 130

• Increase of myeloid suppressor cells (MSC) in chronic collagen induced arthritis (CCIA)

  Tan LA. et al, (2005), IMMUNOLOGY, 116, 69 - 69

• Analysing the effect of novel therapies on cytokine expression in experimental arthritis.

  Williams RO. et al, (2005), International journal of experimental pathology, 86, 267 - 278

• Exploring mechanisms of inflammatory hyperalgesia in murine collagen-induced arthritis

  Inglis JJ. et al, (2005), ARTHRITIS RESEARCH & THERAPY, 7, S44 - S45

• RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: A different interpretation of redundancy (vol 101, pg 18081, 2004)

  Nedvetzki S. et al, (2005), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 1263 - 1263

• Models of rheumatoid arthritis.

  Williams RO., (2005), Ernst Schering Research Foundation workshop, 89 - 117

• Anti-TNF therapy: where have we got to in 2005?

  Feldmann M. et al, (2005), Journal of autoimmunity, 25 Suppl, 26 - 28

• RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy.

  Nedvetzki S. et al, (2004), Proceedings of the National Academy of Sciences of the United States of America, 101, 18081 - 18086

• Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.

  Taylor PC. et al, (2004), Current opinion in biotechnology, 15, 557 - 563

• The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.

  Feldmann M. et al, (2004), Best practice & research. Clinical rheumatology, 18, 59 - 80

• Impact of cAMP on the T-cell response to type II collagen.

  Ozegbe P. et al, (2004), Immunology, 111, 35 - 40

• Collagen-induced arthritis as a model for rheumatoid arthritis.

  Williams RO., (2004), Methods in molecular medicine, 98, 207 - 216

• DEFICIENCY IN A-KINASE ANCHOR PROTEIN EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES FROM PATIENTS WITH SLE

  Williams RO. et al, (2003), RHEUMATOLOGY, 42, 73 - 73

• Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response.

  Mauri C. et al, (2003), Arthritis and rheumatism, 48, 839 - 845

• Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state.

  Williams RO., (2002), Journal of immunology (Baltimore, Md. : 1950), 168, 5392 - 5396

• Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis.

  Marinova-Mutafchieva L. et al, (2002), Arthritis and rheumatism, 46, 507 - 513

• Therapeutic effect of vasoactive intestinal peptide in collagen-induced arthritis.

  Williams RO., (2002), Arthritis and rheumatism, 46, 271 - 273

• Immunotherapy for rheumatoid arthritis.

  Taylor PC. et al, (2001), Current opinion in immunology, 13, 611 - 616

• Joint inflammation in experimental arthritis is preceded by TNFa-dependent infiltration of the synovium by mesenchymal cells.

  Marinova-Mutafchieva L. et al, (2001), ARTHRITIS AND RHEUMATISM, 44, S241 - S241

• Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.

  Malfait AM. et al, (2001), Arthritis and rheumatism, 44, 1215 - 1224

• Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis.

  Gabay C. et al, (2001), Arthritis and rheumatism, 44, 451 - 462

• Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.

  Williams RO. et al, (2000), Journal of immunology (Baltimore, Md. : 1950), 165, 7240 - 7245

• Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha.

  Williams RO. et al, (2000), Annals of the rheumatic diseases, 59 Suppl 1, i75 - i80

• A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-induced arthritis.

  Marinova-Mutafchieva L. et al, (2000), Arthritis and rheumatism, 43, 638 - 644

• Anti-TNF alpha therapy in rheumatoid arthritis--current and future directions.

  Taylor PC. et al, (2000), Current directions in autoimmunity, 2, 83 - 102

Key publications

• Selective tumor necrosis factor receptor I blockade is antiinflammatory and reveals immunoregulatory role of tumor necrosis factor receptor II in collagen-induced arthritis.

  McCann FE. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 2728 - 2738

• Treg cell function in rheumatoid arthritis is compromised by ctla-4 promoter methylation resulting in a failure to activate the indoleamine 2,3-dioxygenase pathway.

  Cribbs AP. et al, (2014), Arthritis & rheumatology (Hoboken, N.J.), 66, 2344 - 2354

• Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.

  Alzabin S. et al, (2012), Annals of the rheumatic diseases, 71, 1741 - 1748

• Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis.

  Criado G. et al, (2009), Arthritis and rheumatism, 60, 1342 - 1351

• Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells.

  Notley CA. et al, (2008), The Journal of experimental medicine, 205, 2491 - 2497

Recent Publications

• Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis.

  Hull DN. et al, (2016), Arthritis research & therapy, 18

• Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis

  Hull DN. et al, (2016), ARTHRITIS RESEARCH & THERAPY, 18

• TNFα in the regulation of Treg and Th17 cells in rheumatoid arthritis and other autoimmune inflammatory diseases.

  Bystrom J. et al, (2016), Cytokine

• Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

  Kawalkowska J. et al, (2016), Scientific reports, 6

• Targeted IL-4 therapy synergizes with dexamethasone to induce a state of tolerance by promoting Treg cells and macrophages in mice with arthritis.

  Kawalkowska JZ. et al, (2016), European journal of immunology, 46, 1246 - 1257