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Published in Science Immunology, researchers at the Kennedy Institute have identified the role of IRF5 in controlling intestinal inflammation.
Johnson Group | Microbiome and Multi-omics
Kennedy
Applying multi-omic and computational genomic approaches to understand the molecular basis of host-microbiome interactions
Buckley Group | Stromal Cell Biology
Inflammation biology Kennedy
We aim to uncover the stromal basis of chronic inflammation and related tissue pathology to target fibroblasts across a range of immune-mediated inflammatory diseases.
Coles Group | Stromal and Systems Immunology
Kennedy
We take an interdisciplinary approach from single-molecule imaging to multi-scale computational modelling and experimental validation to identify and develop therapeutic strategies for immune-mediated inflammatory disease.
Clarke Group | Metabolism and Immunity
Inflammation biology Kennedy
Arthritis Therapy Acceleration Programme
Kennedy
The Arthritis Therapy Acceleration Programme (A-TAP) creates a hub of expertise and infrastructure to support clinical inflammatory disease research to narrow the gap between bench and bedside.
Gérard Group | Spatiotemporal Dynamics of T Cell Responses
Immunity and microbiome Kennedy
We are interested in understanding how CD8 T cell responses are organised in space and time to achieve the correct balance between tolerance and immunity.
Bezbradica Mirkovic Group | Macrophage Biology in Inflammation
Immunity and microbiome Inflammation biology Kennedy
Our research goal is to elucidate mechanisms that control the initiation of inflammatory responses in innate immune cells.
Fritzsche Group | Biophysical Immunology
Kennedy
Primary research goal is the identification and characterisation of the mechanisms of mechanobiology controlling the immune response in health and disease. Our objectives involve the application and development of novel ultrasensitive live-cell microscopy techniques with the right spatiotemporal sensitivity as demanded by the biology. Long-term goal of our research is the translation of our expertise and methodologies in mechanobiology to mechanomedicine in diagnostics and treatment of patients.
Watt Group | Translational Research in Osteoarthritis
Kennedy
Our group tests findings from the laboratory in human clinical studies, and runs experimental medicine studies and clinical trials relevant to osteoarthritis within the Arthritis Research UK Centre for Osteoarthritis Pathogenesis.
RIDD
Kennedy
The RIDD trial aims to test whether the progression of Dupuytren’s disease can be halted or slowed by treatment with anti-TNF injection. Currently, Dupuytren’s disease is left to progress until the finger deformity is severe enough to warrant a surgical procedure in hospital. If successful, anti-TNF treatment would prevent loss of hand function and the need for surgery, and would allow patients to be treated conveniently and quickly.
Powrie Group | Mucosal Immunology
Immunity and microbiome Inflammation biology Kennedy
The Powrie lab employs basic and translational science to study host-microbe crosstalk in health and disease, focussing on inflammatory bowel disease (IBD), colorectal cancer (CRC) and inflammatory arthritis. Research spans observational and functional analysis of a broad range of cell types including bacteria, fibroblasts, T cells and neutrophils.
Sansom Group | Computational and Single Cell Genomics Group
Kennedy
Work in the Sansom lab focuses on identifying the cellular and molecular causes of immune mediated inflammatory disease (IMID) using systems-level approaches.
Williams Group | Targeting Disease Pathways in Rheumatoid Arthritis
Kennedy
Our work is geared towards the development of new treatments and healthcare strategies for rheumatoid arthritis and other autoimmune diseases.
Arnon Group | Lymphocyte Trafficking and Adaptive Immunity
Kennedy
The main focus of the lab is to understand how humoral immune responses are regulated within the spleen.
MEET THE TEAM
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Irina Udalova
Professor of Molecular Immunology
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Fiona Powrie FRS
Professor of Musculoskeletal Sciences and Director of the Kennedy Institute
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Stephen Sansom
Associate Professor
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Alastair Lawrence Corbin
Researcher Assistant in Mucosal Immunology
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Maria Gomez Vazquez
DPhil Student
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Moustafa Attar
Research Associate in Single Cell Genomics
IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation
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