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PATH-2

• Botnar

A pragmatic multi-centre, blinded, randomised placebo-controlled trial comparing Platelet Rich Plasma injection (PRP) to placebo (imitation) injection in adults with Achilles tendon rupture. Two sub-studies are embedded within the main study to contribute to the understanding of the PRP mechanism in tendon healing.

UK STAR

• Botnar

UK Study of Tendo Achilles Rehabilitation

WHITE-4

• Botnar
• Hip

World Hip Trauma Evaluation Four

NINJA

• Botnar

NINJA-P

• Botnar

The NINJA study is a pilot study which will assess whether a study that looks at whether nail plates should be discarded or replaced after nail bed injury in children is feasible in the NHS.

Synthesising a clinical Prognostic Rule for Ankle INjuries in the Emergency Department (SPRAINED)

• Botnar

PROVE

• Botnar

The Physiotherapy Rehabilitation for Osteoporotic Vertebral Fracture (PROVE) study is a clinical trial planning to compare usual care versus an exercise based intervention versus a manual therapy based intervention. It aims to recruit 600 patients from centres across the UK.

RIDD

• Kennedy

The RIDD trial aims to test whether the progression of Dupuytren’s disease can be halted or slowed by treatment with anti-TNF injection. Currently, Dupuytren’s disease is left to progress until the finger deformity is severe enough to warrant a surgical procedure in hospital. If successful, anti-TNF treatment would prevent loss of hand function and the need for surgery, and would allow patients to be treated conveniently and quickly.

OVIVA

• Botnar

To determine whether oral antibiotics are non-inferior to intravenous antibiotics for serious bone and joint infection judged by the percentage of patients experiencing definitive treatment failure during 1 year of follow up.

CSAW

• Botnar
• Shoulder

NDORMS coordinated this multicentre randomised controlled trial (RCT) at 32 hospitals in the UK with 51 surgeons via the Surgical Intervention Trials Unit (SITU) and in collaboration with co-chief investigators Professors David Beard and Andrew Carr. The trial was funded by Arthritis Research UK (Ref.19707)

CORKA

• Botnar
• Knee

The CORKA study was developed in response to a commissioned call by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme for research into a functional home based rehabilitation programme for patients who may be at risk of poor outcome after knee arthroplasty.

Powrie Group | Mucosal Immunology

• Immunity and microbiome
• Inflammation biology
• Kennedy

The Powrie lab employs basic and translational science to study host-microbe crosstalk in health and disease, focussing on inflammatory bowel disease (IBD), colorectal cancer (CRC) and inflammatory arthritis. Research spans observational and functional analysis of a broad range of cell types including bacteria, fibroblasts, T cells and neutrophils.

Nanchahal Group | Treating Fibrosis and Improving Tissue Regeneration

• Kennedy

Sansom Group | Computational and Single Cell Genomics Group

• Kennedy

Work in the Sansom lab focuses on identifying the cellular and molecular causes of immune mediated inflammatory disease (IMID) using systems-level approaches.

Monaco Group | Cardiovascular Inflammation

• Kennedy

Dustin, M Group | Immunological Synapse

• Kennedy

AIM

• Botnar

A pragmatic UK multi-centre randomised controlled trial comparing Close Contact Casting technique (CCC) to Open Surgical Reduction and Internal Fixation (ORIF) in the treatment of unstable ankle fractures in patients over 60 years of age.

Williams Group | Targeting Disease Pathways in Rheumatoid Arthritis

• Kennedy

Our work is geared towards the development of new treatments and healthcare strategies for rheumatoid arthritis and other autoimmune diseases.

Arnon Group | Lymphocyte Trafficking and Adaptive Immunity

• Kennedy

The main focus of the lab is to understand how humoral immune responses are regulated within the spleen.

Centre for Sport, Exercise and Osteoarthritis

• Botnar