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The Aspirin Esomeprazole Chemoprevention Trial (AspECT) is to our knowledge one of the largest cancer prevention trials using aspirin and acid suppression in the world. In total 2557 patients with a common precancerous change in their oesophagus, called Barrett’s oesophagus, were followed up for an average of 9 years resulting in over 20,000 life-years of follow up. After informed written consent, patients were randomly allocated to four different combinations; Low acid suppression alone, High acid suppression alone, low acid suppression with 300mg aspirin and high acid suppression with 300mg aspirin. We wanted to see if we could prevent progression to local cancer/cancer in-situ (high grade dysplasia), invasive cancer or prevent death by all causes both cancer and non-cancer.
DRAFT3 – CASP
This trial aims to compare two treatment methods that are currently standard care for treating wrist fractures. There are a large number of wrist fractures every year in the UK and by comparing the clinical and cost effectiveness of the treatments, this could help save money for the NHS.
WISE
Progressive resistance and flexibility exercises versus usual care advice for improving pain and function after distal radius fracture in adults aged 50 years or over: the WISE randomised superiority trial
FRUITI
World Hip Trauma Evaluation - FRUITI: Fix or Replace Undisplaced Intracapsular fractures Trial of Interventions
CRAFFT
Children’s Radius Acute Fracture Fixation Trial. A multi-centre prospective randomized non- inferiority trial of surgical reduction versus non-surgical casting for displaced distal radius fractures in children.