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Dendrou Group | Immune Disease Multiomics

Our research aims to compare inflammatory diseases and immunological responses across tissues, over time and upon perturbation for translational benefit, leveraging multiomic technologies.

The CELLOS Study

Development of a core outcome set for children’s elective lower limb orthopaedic surgery

ACL STARR

OCTRU SITU

Anterior Cruciate Ligament Stratified Accelerated Repair or Reconstruction Single blind randomised control trial for patients with proximal ACL injuries treatment with ACL repair v ACL reconstruction.

WHiTE-13 DECI

This study has been designed following a James Lind Alliance Patient and Public Research Priority Setting Partnership, which identified the following question as a key research priority: “What are the best treatments to prevent and treat confusion and delirium after surgery in adults with a broken bone in the leg?”

Public perceptions of health data sharing for AI Research: the PHAIR study

The aim of this study is to explore what the UK public think about sharing their health data to develop and test artificial intelligence (AI).

Promote

Fullerton Group | Translational Pharmacology

The Translational Pharmacology group focuses on the use of human experimental medicine studies to achieve scientific insight for patient benefit.

HIPCARE

With rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?

HIPCARE

With rapidly ageing populations in Asia, the number of patients at risk of hip fractures is increasing. Can a multidisciplinary training and support package ('HIPCARE') improve quality of life and reduce healthcare costs for patients with hip fracture?

ODD SOCKS

A multi-centre prospective randomised superiority trial of conservative versus surgical treatment for displaced distal tibial fractures in children aged 8-15 years.

FORENSIC

OCTRU SITU

The clinical and cost-effectiveness of lumbar fusion surgery for patients with persistent, severe low back pain: Short: FusiOn veRsus bEst coNServatIve Care.

Progatzky Group | Peripheral glia and immunity

Our research aims to elucidate the role of peripheral glial cells in tissue health and disease.

BigBOSS

The Big BOSS Study- The British Orthopaedic Slipped Capital Femoral Epiphysis (SCFE) Surgery Study for Severe Stable Slips. A multi-centre prospective randomised superiority trial of an acute deformity correction versus pinning in-situ for severe stable SCFE in children.

ADOPT

Osteoporosis is a common bone disease that causes weaker bones that break after a fall and lead to chronic severe pain and life-changing complications. There are treatments available that strengthen bones and lower the chance of another fracture. Many hospitals have specialist teams dedicated to finding patients who have broken a bone to prevent the next fracture. We know breaking a bone in the spine, a spine fracture, is a critical sign of osteoporosis. However, most patients don't realise they have a spine fracture as they cause temporary back pain that is often ignored. We know that over three million people have scans that include the spine, for other reasons such as lung or bowel problems. Up to 1 in 20 scans could be showing there is a spine fracture. Currently, very few fractures are recognised or acted upon. This project will use an innovative Artificial Intelligence (AI) software that automatically looks at existing CT scans to find these spine fractures and brings them directly to the specialist team's attention, to see if the patient needs bone-strengthening lifestyle advice and medicines. We call this an 'AI-enabled spine fracture pathway'. We will show that using the pathway will improve patient health and reduce costs to hospitals using multiple methods.

Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network

Botnar

Creating a global atlas of the musculoskeletal system

Ancestrally Inclusive Musculoskeletal Single-cell (AIMS) Network

Creating a global atlas of the musculoskeletal system

ROBUST

OCTRU RRIO SITU

Clinical effectiveness of an adolescent-specific strengthening programme, compared to usual care, for ambulant adolescents with spastic cerebral palsy (ROBUST trial): a parallel group randomised controlled trial.

SPELL

OCTRU RRIO SITU

Clinical effectiveness of a child-specific dynamic stretching programme, compared to usual care, for ambulant children with spastic cerebral palsy (SPELL trial): a parallel group randomised controlled trial.

Health Economics & Outcomes Research

Arthritis Botnar Orthopaedics and trauma Statistics and epidemiology

Our research aims to improve people's health and wellbeing by making the most efficient use of health and social care resources. To achieve this, we use real-world data and mathematical models to evaluate the costs and consequences of applying different interventions over a period of time, often the entire lifetime of patients.

GEKO

OCTRU SITU

Genicular Artery Embolisation for the symptomatic treatment of knee osteoarthritis refractory to conservative management