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Jonathan Cook

BSc, PhD, CStat


Associate Professor

  • University Lecturer

Expertise in medical statistics, especially clincial trials and surgery research

Jonathan’s main research interest is in the design, conduct, analysis and reporting of randomised controlled trials, particularly surgical trials. His specific areas of interest include the specification of the target difference in the sample size calculation, addressing interventional expertise and methods for improving recruitment. Jonathan has extensive experience in systematic reviews of randomised controlled trials and diagnostic research. He has collaborated on numerous projects, including randomised trials, observational and diagnostic studies, methodological projects and systematic reviews in a variety of clinical areas, such as anaesthesia, cardiovascular research, obstetrics and gynaecology, ophthalmology, orthopaedics, primary care, general surgery and urology. Particular methodological contributions have been in the design and analysis of surgical trials (including the handling of surgical expertise and addressing non-compliance to treatment allocation), and also specifying the target difference in definitive ("Phase III") randomised trials. A news article related to the DELTA2 guidance, of which a summary paper was recently published in the BMJ and Trials journals, is available here.

Jonathan leads a programme of his own research and is the lead investigator of the DELTA2 and PARCS projects and co-lead of the NIHR-MRC funded placebo surgery guidance project.  Jonathan is a lead statistician within the Oxford Clinical Trials Research Unit (OCTRU) and he oversees a group of five statisticians. His current clinical projects include the grant funded ACL SNNAP, BioYarn, DRAFFT2, MACRO, NINJA, ORIF, PARCS, and TOPKAT. He is a Deputy Director of the Surgical Intervention Trials Unit (SITU). Jonathan supervises a number of postgraduate students based both in Oxford and elsewhere on topics related to trials methodology. He also tutors undergraduate students and teaches and examines postgraduate (DPhil and Masters level) students on the methodology of clinical trials, systematic reviews and the related use of medical statistics. Jonathan also has a number of other internal managerial and budgetary responsibilities. He has also undertaken external consultancy as a medical statistics expert (including legal work). 

Jonathan graduated from the University of Aberdeen with a BSc in Statistics. He undertook a PhD on the statistical assessment of learning curve effects in randomised controlled trials. Subsequently, he worked at the Health Services Research Unit, University of Aberdeen as a statistician. In August 2007, he started an MRC UK Fellowship focusing on methodology related to the design, conduct and analysis of surgical randomised trials. As part of this fellowship, he spent 12 months working at the Ottawa Hospital Research Institute in Canada before returned to the Health Services Research Unit in August 2009 to take up a position as a methodologist. In 2011, he was awarded an MRC UK Methodology Fellowship focusing on expertise-based trial designs and in August 2012 became a Senior Research Fellow. He joined the Centre for Statistics in Medicine (CSM) in 2013 on a secondment, during which he was appointed to a University Lectureship in NDORMS, University of Oxford.

Jonathan holds a number of external responsibilities. He serves on and chairs Data Monitoring and Steering committees for a number of clinical trials and was recently appointed as a Deputy Editor of Clinical Trials, a member of the Editorial Board of Trials journal and a statistical consultant for the British Journal of Surgery. Other responsibilities include serving on grant funding committees (e.g., for the NIHR's Health Technology Assessment and Research for Patient Benefit programmes) and membership of the IDEAL collaboration's steering group and of the ConDucT-II MRC Hub for Trials Methodology Research.

He has over 200 publications including 130 full journal articles, more than 25 as first author, and over 20 as senior author in leading medical, clinical trials, methodology and epidemiology journals. 

Jonathan's ORCID number is 0000-0002-4156-6989, his Google Scholar account is available here, and his twitter handle is @ProfJACook.

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