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A new study published in the Journal of Experimental Medicine reveals how IL-10 and PGE2 work together to prevent inflammatory tissue damage and maintain a healthy gut balance

Macrophage engulfing bacteria 3d illustration © Shutterstock
The new study shows the IL-10-PGE2 axis ensures macrophages are effective at killing potentially harmful bacteria
Srinivasa Rao Rao

Srinivasa Rao Rao

MBBS, MS (res), DPhil, AFHEA Srinivasa Rao Rao - Senior Researcher in Cancer Genomics

Chen-Yi Wang

Chen-Yi Wang

Chen-Yi Wang - Senior Research Associate

Irina Udalova

Irina Udalova

Irina Udalova - Professor of Molecular Immunology

Lina Akinyi

Lina Akinyi - DPhil student

Ed Wheeler

Ed Wheeler - DPhil student

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Amy O’Connor - DPhil student

Akira Wiberg

Akira Wiberg

BA BM BCh DPhil FRCS(Plast) Akira Wiberg - Senior Clinical Research Fellow

Wesley Tung

Wesley Tung - DPhil student

Nianna Kjelstrup-Osorio

Nianna Kjelstrup-Osorio - DPhil student

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Juan Espitia Jaramillo - DPhil student

Alexander Maslaris

Alexander Maslaris

Alexander Maslaris - Senior Clinical Research Fellow

Charlotte Bell

Charlotte Bell - Program Director – Industry Liaison in Experimental Medicine

Anil Prabhu

Anil Prabhu - Clinical Research Fellow in Gastroenterology

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Ioana Marian

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Gary Collins

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  • Fiona Powrie FRS
    Fiona Powrie FRS

    Professor of Musculoskeletal Sciences and Director of the Kennedy Institute

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Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2
Journal of Experimental Medicine

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