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No link found between patient genetics and response to anti-IL17 therapy
Kennedy Main Publication
4 September 2023
A new study looked at the effect of patient genetics on their response to secukinumab, an anti-IL17 therapy commonly used to treat inflammatory conditions including arthritis and psoriasis. No link was found between a patient’s genetic variants and their response to therapy. This study challenges the idea that genetics might significantly account for the variable responses to anti-IL17 therapy seen in the clinic.
New therapeutic targets identified to treat inflammatory bowel disease
Kennedy Main Publication
22 October 2021
Millions of patients with ulcerative colitis or Crohn’s disease, collectively known as inflammatory bowel disease (IBD), are given fresh hope as a new study shows why some of them do not respond to current treatments.
The rationale and ethics of placebo controls in surgical trials
Main Publication
20 March 2020
A new Review, published in the Lancet, analyses the use of placebo controls in surgery and offers a practical checklist for researchers designing trials.
Platelet rich plasma found to be of no benefit in treating torn Achilles tendon
Main OCTRU Publication RRIO
20 November 2019
New research from the University of Oxford has shown that platelet rich plasma (PRP) is not effective in treating acute Achilles tendon ruptures.
Largest study of its kind provides real-world evidence of the benefits of partial versus total knee replacement
Botnar Knee Main OCTRU Publication
8 November 2019
Opioid use and additional post-operative complications have been shown to be reduced when partial knee replacement is used over surgery where the whole of the joint is replaced.
Excellence payments to hospitals improve hip fracture care in England
Botnar Hip Main Orthopaedics and trauma Publication Trauma
1 August 2019
A scheme that pays hospitals to deliver high quality care has been shown to improve the outcomes for patients with broken hips in England.
Increased use of partial knee replacement could save the NHS £30 million per year
Botnar Knee Main Publication SITU Trials
17 July 2019
New research from a randomised clinical trial published today in The Lancet and funded by the National Institute for Health Research (NIHR) shows that partial knee replacements (PKR) are as good as total knee replacements (TKR), whilst being more cost effective.
Key link discovered between tissue cell type and different forms of arthritis
Arthritis Kennedy Main Publication Translational medicine
29 May 2019
Pioneering research by scientists at the Universities of Oxford and Birmingham published today in Nature brings us a step closer to developing targeted therapies for inflammatory diseases.
Vaccine developed to treat osteoarthritic pain
Kennedy Main OACentre Publication
12 March 2019
Researchers have developed a vaccine that blocks the effects of the main cause of pain in osteoarthritis (OA) - nerve growth factor (NGF) - in mice.
Genes and height matter for carpal tunnel syndrome
Botnar Main Publication
4 March 2019
Researchers from the University of Oxford and Estonia have found further evidence that a person’s genetic make-up and height can influence whether they will develop carpal tunnel syndrome (CTS).
Risks of shoulder replacement surgery higher than previously thought
Botnar Main Orthopaedics and trauma Publication
20 February 2019
Need for further surgery particularly high in younger men and serious complications surprisingly common in older people, say researchers.
New drug class could offer a targeted safer treatment alternative for patients with rheumatoid arthritis
Arthritis Kennedy Main Publication
15 February 2019
A new treatment targeting tenascin-C could reduce the progression and severity of rheumatoid arthritis (RA) at the very early stages of disease.
Study suggests immune system plays key role in survival after pancreatic cancer surgery
Kennedy Main Publication
12 February 2019
Researchers in Oxford have found that an individual’s immune system – and in particular the presence of T-cells amongst tumour cells – may play an important role in survival after surgery to remove pancreatic cancer.
One step closer to targeted therapies for joint inflammation
Department Inflammation biology Main Publication
4 January 2019
New discoveries on how tissue cells, known as stromal cells contribute to chronic joint inflammation could hold the key to innovative targeted treatments for patients with refractory joint disease.
CBT-O protocol published
Publication RRIO
17 December 2018
Protocol for an overview of systematic reviews into the effectiveness of CBT
Improving the reporting of patent landscapes for better decision-making
Botnar Main Publication
16 November 2018
An international panel of experts led by NDORMS researchers has developed a reporting guideline which supports the reporting quality of patent landscapes, ultimately promoting better informed decision-making in technology development and research direction.
Getting sample sizes right for clinical trials
Botnar CSM Main Publication Statistics and epidemiology
6 November 2018
New guidance published yesterday by a team led by NDORMS Associate Professor Jonathan Cook will help researchers recruit the right number of people for clinical trials and answer key research questions.
New clinical tool will help patients with acute ankle sprain
Botnar CSM Main Publication Rehabilitation and self-management Statistics and epidemiology
6 November 2018
Patients arriving at hospital emergency departments with acute ankle sprains can expect more timely advice and follow-up care in future after researchers in Oxford developed a new tool that will aid clinical decisions on treatment.
Muscle weakness costs the UK £2.5 billion
Botnar Main Publication Statistics and epidemiology
16 October 2018
UK health and social care costs due to muscle weakness amount to around £2.5 billion according to a new study carried out at the University of Oxford and the University of Southampton.
Oxford scientists discover key factor that ‘alerts’ stem cells to accelerate healing of multiple tissues
Kennedy Main Orthopaedics and trauma Publication
27 April 2018
Researchers at the Kennedy Institute, University of Oxford have found that a single administration of a molecule accelerated healing of multiple tissues when administered after or even before injury.