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NEOPANC-01 is a window of opportunity study looking to assess gene expression in patients with resectable pancreatic cancer. It aims to evaluate the utility of whole transcriptome RNA sequencing as a potential biomarker for future window-of-opportunity trials that will assess existing and/or new treatments for pancreatic cancer. An understanding of the variability in the transcriptomic signature between biopsies will also inform power calculations for future studies. Lastly, the data generated will be available for use as historical controls for future studies. 2 sets of biopsy samples will be taken throughout the trial. Firstly during an endoscopic ultrasound procedure and then again, up to 6 weeks later, during the patients surgery to remove the cancer. Once all patients have been recruited, the mRNA from the samples will be sequenced and analysed. Further samples will also be taken at the same time points for storage into a biobank and for use in future research. This is a single site study opening at the Churchill Hospital looking to recruit 10 patients over 18 months.
Sara Khalid
Botnar CSM Principal Investigators
BE, MSc (Oxon), DPhil Sara Khalid - Associate Professor of Health Informatics and Biomedical Data Science
Srinivasa Rao Rao
Research Scientists
MBBS, MS (res), DPhil, AFHEA Srinivasa Rao Rao - Principal Investigator
Philippa Hulley
Botnar Principal Investigators
BSc Med, BSc Med (Hons), PhD Philippa Hulley - Associate Professor
Antonella Delmestri
Botnar CSM Research Scientists
PhD Antonella Delmestri - Lead Health Data Scientist
Maria Sanchez Santos
Botnar CSM Research Scientists
BSc, MSc Maria Sanchez Santos - Senior Research Associate in Epidemiology and Medical Statistic
Adrian Kendal
Honorary staff
MA (Oxon.) BMBCh, DPhil (Oxon.), FRCS (Ortho.) Adrian Kendal - Honorary Senior Clinical Lecturer
Vicki Barber
Botnar CSM OCTRU Research Delivery Research Scientists
BSc (Hons) ; FIoB; PhD Vicki Barber - OCTRU Operations Director
Gary Collins
CSM Principal Investigators
PhD Gary Collins - Professor of Medical Statistics and Director of CSM
Karene Argoud
Kennedy Research Scientists
Karene Argoud - Single-Cell and Spatial Genomics Operations Technician
Dave Banfield
Botnar Facilities Professional Services
Dave Banfield - Buildings and Facilities Manager
Siim Pauklin
Botnar Principal Investigators
Siim Pauklin - Associate Professor and CRUK Career Development Fellow
Andrew Carr
OCTRU Principal Investigators
MA ChM DSc FRCS FMedSci Andrew Carr - Nuffield Professor of Orthopaedics
Katie Chegwin
Botnar Professional Services SITU
Katie Chegwin - Personal Assistant to Professor David Beard
Hanna Boddy
Kennedy Professional Services
Hanna Boddy - Executive Assistant to the Director of the Kennedy Institute
Ivy Raymundo Wood
Research Delivery SITU
BSc (Hons) Ivy Raymundo Wood - Senior Clinical Trial Manager