Contact information
Research Students
Alejandro Gomez (DPhil Student) |
| Conor Hennessy (AFP) |
Colleges
FUNDING BODIES
British Othopaedic Foot Ankle Society
Royal College Surgeons
Adrian Kendal
MA (Oxon.) BMBCh, DPhil (Oxon.), FRCS (Ortho.)
Honorary Senior Clinical Lecturer
- Honorary Senior Clinical Lecturer, University Of Oxford
- Specialist Orthopaedic Surgeon with subspecialty interest in Foot and Ankle Reconstruction
- Lecturer at Trinity College, Oxford
Adrian's research aim is to understand the pathogenesis of chronic debilitating tendon disease. Tendon disease accounts for over 20% of primary care consultations and represents a growing healthcare challenge in an active and increasingly ageing population. Recognising critical cells involved in tendinopathy is essential in developing therapeutics to meet this challenge.
Adrian has applied combined single cell transcriptomics and surface proteomics to identify novel tendon cell sub-types in diseased and healthy human tendon. For the first time, he has shown that human tendon harbours multiple distinct COL1A1/2 expressing tenocyte populations in addition to endothelial cells, T-cells, and monocytes. Adrian is interested in the temporal-spatial interaction of particular tendon cell sub-types in the pathogenesis of chronic tendinopathy, for example pro-inflammatory PTX3 cells and signalling pathways.
Recent publications
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Single-stage orthoplastic treatment of complex calcaneal osteomyelitis with large soft-tissue defects.
Down B. et al, (2024), Bone joint j, 106-B, 1443 - 1450
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Predictors of poor pre-operative patient reported outcome measures in elective foot and ankle surgery: Analysis of 1217 patients.
Talia AJ. et al, (2024), Foot (edinb), 61
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The Outcomes of Isolated Tibiocalcaneal Arthrodesis: A Systematic Review.
Cossins C. et al, (2024), Foot ankle orthop, 9
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TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair.
Cherief M. et al, (2023), Sci transl med, 15
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Association of Preexisting Triple Fusion and Arthroscopic Ankle Arthrodesis nonunion.
Woods A. et al, (2023), Foot ankle int
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Long-Term Follow-up of Complex Calcaneal Osteomyelitis Treated With Modified Gaenslen Approach.
Kendal A. et al, (2022), Foot ankle orthop, 7
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The Application and Patient-Reported Experience of Telephone Consultations in Elective Foot and Ankle Orthopaedic Surgery: 12-Month Follow-up.
Sharma A. et al, (2022), Foot ankle int, 43, 694 - 702
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Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendon.
Kendal AR. et al, (2020), Sci rep, 10
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Identification of human tendon cell populations in healthy and diseased tissue using combined single cell transcriptomics and proteomics
Kendal AR. et al, (2019)
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Conversion rate of isolated talo-calcaneal (subtalar) arthrodesis to triple fusion; five year study
(2018), Foot and ankle surgery
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Resorbable electrospun polydioxanone fibres modify the behaviour of cells from both healthy and diseased human tendons.
Kendal A. et al, (2017), Eur cell mater, 33, 169 - 182
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Fracture healing in the elderly: A review.
Foulke BA. et al, (2016), Maturitas, 92, 49 - 55