CRUK Career development fellow
- Principal Investigator
Dr Siim Pauklin is a Cancer Research UK Career Development Fellow leading a research group in the Botnar Research Centre at University of Oxford.
His scientific interests cover stem cell biology and cancer research, with a particular focus on molecular mechanisms that regulate cancer stem cell formation. This research aims to understand the signal transduction / transcription pathways that control tissue transformation and the stem cell-like characteristics of cancer stem cells in human malignancies. The long-term goal of his research is to uncover molecular mechanisms that can be targeted by novel and more efficient cancer therapeutics.
Dr Pauklin obtained his BSc in 2004 and MSc in 2005 at University of Tartu in the laboratory of Prof. Toivo Maimets. In 2005, he joined the laboratory of Dr Svend Petersen-Mahrt at CRUK London Research Institute / Clare Hall Laboratories for his graduate studies on Activation Induced Cytidine Deaminase and obtained a PhD in Biochemistry and Molecular Biology from University College London in 2009. He did his postdoctoral research studying the self-renewal and differentiation of human pluripotent stem cells in the laboratory of Prof. Ludovic Vallier in University of Cambridge. Dr Pauklin has also given lecture series as a visiting lecturer in University of Tartu in his home country Estonia.
PAF1 regulates the stemness of pancreatic cancer stem cells
Feng Y. et al, (2021), Gastroenterology
TGFB1/INHBA Homodimer/Nodal-SMAD2/3 Signaling Network: A Pivotal Molecular Target in PDAC Treatment
Abdel Mouti M. and PAUKLIN S., (2021), Molecular therapy
3D chromatin architecture and epigenetic regulation in cancer stem cells
Feng Y. et al, (2020), Protein and cell
Epigenetics of Cancer Stem Cell Formation and Maintenance
French R. and PAUKLIN S., (2020), International journal of cancer
Molecular therapeutics of pancreatic ductal adenocarcinoma:
targeted pathways and the role of cancer stem cells
Stoica A. et al, (2020), Trends in pharmacological sciences