CRUK Career development fellow
- Principal Investigator
Dr Siim Pauklin is a Cancer Research UK Career Development Fellow leading a research group in the Botnar Research Centre at University of Oxford.
His scientific interests cover stem cell biology and cancer research, with a particular focus on molecular mechanisms that regulate cancer stem cell formation. This research aims to understand the signal transduction / transcription pathways that control tissue transformation and the stem cell-like characteristics of cancer stem cells in human malignancies. The long-term goal of his research is to uncover molecular mechanisms that can be targeted by novel and more efficient cancer therapeutics.
Dr Pauklin obtained his BSc in 2004 and MSc in 2005 at University of Tartu in the laboratory of Prof. Toivo Maimets. In 2005, he joined the laboratory of Dr Svend Petersen-Mahrt at CRUK London Research Institute / Clare Hall Laboratories for his graduate studies on Activation Induced Cytidine Deaminase and obtained a PhD in Biochemistry and Molecular Biology from University College London in 2009. He did his postdoctoral research studying the self-renewal and differentiation of human pluripotent stem cells in the laboratory of Prof. Ludovic Vallier in University of Cambridge. Dr Pauklin has also given lecture series as a visiting lecturer in University of Tartu in his home country Estonia.
Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D.
Pauklin S. et al, (2016), Genes & development, 30, 421 - 433
Regulation of Activation Induced Deaminase (AID) by Estrogen.
Pauklin S., (2016), Methods in molecular biology (Clifton, N.J.), 1366, 561 - 572
Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.
Bertero A. et al, (2015), Genes & development, 29, 702 - 717
Activin/Nodal signalling in stem cells.
Pauklin S. and Vallier L., (2015), Development (Cambridge, England), 142, 607 - 619
Human stem cells for craniomaxillofacial reconstruction.
Jalali M. et al, (2014), Stem cells and development, 23, 1437 - 1451