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NEOPANC-01 is a window of opportunity study looking to assess gene expression in patients with resectable pancreatic cancer. It aims to evaluate the utility of whole transcriptome RNA sequencing as a potential biomarker for future window-of-opportunity trials that will assess existing and/or new treatments for pancreatic cancer. An understanding of the variability in the transcriptomic signature between biopsies will also inform power calculations for future studies. Lastly, the data generated will be available for use as historical controls for future studies. 2 sets of biopsy samples will be taken throughout the trial. Firstly during an endoscopic ultrasound procedure and then again, up to 6 weeks later, during the patients surgery to remove the cancer. Once all patients have been recruited, the mRNA from the samples will be sequenced and analysed. Further samples will also be taken at the same time points for storage into a biobank and for use in future research. This is a single site study opening at the Churchill Hospital looking to recruit 10 patients over 18 months.
Vicki Barber
Botnar CSM OCTRU Research Delivery Research Scientists
BSc (Hons) ; FIoB; PhD Vicki Barber - OCTRU Operations Director
Andrew Carr
OCTRU Principal Investigators
MA ChM DSc FRCS FMedSci Andrew Carr - Nuffield Professor of Orthopaedics
Joanna Black
Botnar CSM OCTRU Research Delivery
BSc, PhD Joanna Black - OCTRU Head of Regulatory Affairs and Quality Assurance (HoRAQ)
Anne Francis
Botnar OCTRU Research Scientists
D.Phil Anne Francis - Clinical Trial Operational Lead – Experimental Medicine and Rheumatology
Emma Phelps
Botnar Kadoorie OCTRU Research Scientists
Emma Phelps - Postdoctoral Research Associate in Mixed Methods Research
Esther Williamson
Botnar OCTRU Research Scientists
Esther Williamson - Deputy Director, Centre for Rehabilitation Research in Oxford
Susan Wagland
Botnar Kadoorie OCTRU Research Delivery
BA, BSc, MSc, PhD Susan Wagland - Clinical Trials Manager
Emma Haines
Botnar CSM OCTRU Research Delivery
Emma Haines - OCTRU - Quality Assurance and Administration Manager